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Chronic Human Pegivirus 2 without Hepatitis C Virus Co-infection

Most human pegivirus 2 (HPgV-2) infections are associated with past or current hepatitis C virus (HCV) infection. HPgV-2 is thought to be a bloodborne virus: higher prevalence of active infection has been found in populations with a history of parenteral exposure to viruses. We evaluated longitudina...

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Autores principales: Coller, Kelly E., Bruce, Veronica, Cassidy, Michael, Gersch, Jeffrey, Frankel, Matthew B., Vallari, Ana, Cloherty, Gavin, Hackett, John, Evans, Jennifer L., Page, Kimberly, Dawson, George J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986836/
https://www.ncbi.nlm.nih.gov/pubmed/31961294
http://dx.doi.org/10.3201/eid2602.190434
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author Coller, Kelly E.
Bruce, Veronica
Cassidy, Michael
Gersch, Jeffrey
Frankel, Matthew B.
Vallari, Ana
Cloherty, Gavin
Hackett, John
Evans, Jennifer L.
Page, Kimberly
Dawson, George J.
author_facet Coller, Kelly E.
Bruce, Veronica
Cassidy, Michael
Gersch, Jeffrey
Frankel, Matthew B.
Vallari, Ana
Cloherty, Gavin
Hackett, John
Evans, Jennifer L.
Page, Kimberly
Dawson, George J.
author_sort Coller, Kelly E.
collection PubMed
description Most human pegivirus 2 (HPgV-2) infections are associated with past or current hepatitis C virus (HCV) infection. HPgV-2 is thought to be a bloodborne virus: higher prevalence of active infection has been found in populations with a history of parenteral exposure to viruses. We evaluated longitudinally collected blood samples obtained from injection drug users (IDUs) for active and resolved HPgV-2 infections using a combination of HPgV-2–specific molecular and serologic tests. We found evidence of HPgV-2 infection in 11.2% (22/197) of past or current HCV-infected IDUs, compared with 1.9% (4/205) of an HCV-negative IDU population. Testing of available longitudinal blood samples from HPgV-2–positive participants identified 5 with chronic infection (>6 months viremia in >3 timepoints); 2 were identified among the HCV-positive IDUs and 3 among the HCV-negative IDUs. Our findings indicate that HPgV-2 can establish chronic infection and replicate in the absence of HCV.
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spelling pubmed-69868362020-02-06 Chronic Human Pegivirus 2 without Hepatitis C Virus Co-infection Coller, Kelly E. Bruce, Veronica Cassidy, Michael Gersch, Jeffrey Frankel, Matthew B. Vallari, Ana Cloherty, Gavin Hackett, John Evans, Jennifer L. Page, Kimberly Dawson, George J. Emerg Infect Dis Research Most human pegivirus 2 (HPgV-2) infections are associated with past or current hepatitis C virus (HCV) infection. HPgV-2 is thought to be a bloodborne virus: higher prevalence of active infection has been found in populations with a history of parenteral exposure to viruses. We evaluated longitudinally collected blood samples obtained from injection drug users (IDUs) for active and resolved HPgV-2 infections using a combination of HPgV-2–specific molecular and serologic tests. We found evidence of HPgV-2 infection in 11.2% (22/197) of past or current HCV-infected IDUs, compared with 1.9% (4/205) of an HCV-negative IDU population. Testing of available longitudinal blood samples from HPgV-2–positive participants identified 5 with chronic infection (>6 months viremia in >3 timepoints); 2 were identified among the HCV-positive IDUs and 3 among the HCV-negative IDUs. Our findings indicate that HPgV-2 can establish chronic infection and replicate in the absence of HCV. Centers for Disease Control and Prevention 2020-02 /pmc/articles/PMC6986836/ /pubmed/31961294 http://dx.doi.org/10.3201/eid2602.190434 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Coller, Kelly E.
Bruce, Veronica
Cassidy, Michael
Gersch, Jeffrey
Frankel, Matthew B.
Vallari, Ana
Cloherty, Gavin
Hackett, John
Evans, Jennifer L.
Page, Kimberly
Dawson, George J.
Chronic Human Pegivirus 2 without Hepatitis C Virus Co-infection
title Chronic Human Pegivirus 2 without Hepatitis C Virus Co-infection
title_full Chronic Human Pegivirus 2 without Hepatitis C Virus Co-infection
title_fullStr Chronic Human Pegivirus 2 without Hepatitis C Virus Co-infection
title_full_unstemmed Chronic Human Pegivirus 2 without Hepatitis C Virus Co-infection
title_short Chronic Human Pegivirus 2 without Hepatitis C Virus Co-infection
title_sort chronic human pegivirus 2 without hepatitis c virus co-infection
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986836/
https://www.ncbi.nlm.nih.gov/pubmed/31961294
http://dx.doi.org/10.3201/eid2602.190434
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