GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

Transcriptional repression needs to be rapidly reversible during embryonic development. This extends to the Hedgehog pathway, which primarily serves to counter GLI repression by processing GLI proteins into transcriptional activators. In investigating the mechanisms underlying GLI repression, we fin...

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Detalles Bibliográficos
Autores principales: Lex, Rachel K, Ji, Zhicheng, Falkenstein, Kristin N, Zhou, Weiqiang, Henry, Joanna L, Ji, Hongkai, Vokes, Steven A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986877/
https://www.ncbi.nlm.nih.gov/pubmed/31989924
http://dx.doi.org/10.7554/eLife.50670

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