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mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

Central to cellular metabolism and cell proliferation are highly conserved signalling pathways controlled by mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK)(1,2), dysregulation of which are implicated in pathogenesis of major human diseases such as cancer and type 2 diab...

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Detalles Bibliográficos
Autores principales:	Ling, Naomi X.Y., Kaczmarek, Adrian, Hoque, Ashfaqul, Davie, Elizabeth, Ngoei, Kevin R.W., Morrison, Kaitlin R., Smiles, William J., Forte, Gabriella M., Wang, Tingting, Lie, Shervi, Dite, Toby A., Langendorf, Christopher G., Scott, John W., Oakhill, Jonathan S., Petersen, Janni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986917/ https://www.ncbi.nlm.nih.gov/pubmed/31993556 http://dx.doi.org/10.1038/s42255-019-0157-1

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