Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin

BACKGROUND: Epidemiological studies suggest that metformin may reduce the incidence of cancer in patients with diabetes and multiple late phase clinical trials assessing the potential of repurposing this drug are underway. Transcriptomic profiling of tumour samples is an excellent tool to understand...

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Detalles Bibliográficos
Autores principales: Lord, Simon R., Collins, Jennifer M., Cheng, Wei-Chen, Haider, Syed, Wigfield, Simon, Gaude, Edoardo, Fielding, Barbara A., Pinnick, Katherine E., Harjes, Ulrike, Segaran, Ashvina, Jha, Pooja, Hoefler, Gerald, Pollak, Michael N., Thompson, Alastair M., Roy, Pankaj G., English, Ruth., Adams, Rosie F., Frezza, Christian, Buffa, Francesca M., Karpe, Fredrik, Harris, Adrian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986920/
https://www.ncbi.nlm.nih.gov/pubmed/31819193
http://dx.doi.org/10.1038/s41416-019-0665-5

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