Cargando…

Morule-like features in pulmonary adenocarcinoma associated with epidermal growth factor receptor mutations: two case reports with targeted next-generation sequencing analysis

Morules, or morule-like features, can be identified in benign and malignant lesions in various organs. Morular features are unusual in pulmonary adenocarcinoma cases with only 26 cases reported to date. Here, we describe two cases of pulmonary adenocarcinoma with morule-like features in Korean women...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Yoo Jin, Oh, Harim, Kim, Eojin, Ahn, Bokyung, Lee, Jeong Hyeon, Lee, Youngseok, Chae, Yang Seok, Kim, Chul Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists and the Korean Society for Cytopathology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986969/
https://www.ncbi.nlm.nih.gov/pubmed/31674165
http://dx.doi.org/10.4132/jptm.2019.09.30
_version_ 1783492055106846720
author Lee, Yoo Jin
Oh, Harim
Kim, Eojin
Ahn, Bokyung
Lee, Jeong Hyeon
Lee, Youngseok
Chae, Yang Seok
Kim, Chul Hwan
author_facet Lee, Yoo Jin
Oh, Harim
Kim, Eojin
Ahn, Bokyung
Lee, Jeong Hyeon
Lee, Youngseok
Chae, Yang Seok
Kim, Chul Hwan
author_sort Lee, Yoo Jin
collection PubMed
description Morules, or morule-like features, can be identified in benign and malignant lesions in various organs. Morular features are unusual in pulmonary adenocarcinoma cases with only 26 cases reported to date. Here, we describe two cases of pulmonary adenocarcinoma with morule-like features in Korean women. One patient had a non-mucinous-type adenocarcinoma in situ and the other had an acinarpredominant adenocarcinoma with a micropapillary component. Both patients showed multiple intra-alveolar, nodular, whorled proliferative foci composed of atypical spindle cells with eosinophilic cytoplasm. Targeted next-generation sequencing was performed on DNA extracted from formalin-fixed paraffin-embedded samples of the tumors. Results showed unusual epidermal growth factor receptor (EGFR) mutations, which are associated with drug resistance to EGFR tyrosine kinase inhibitors, revealing the importance of identifying morule-like features in pulmonary adenocarcinoma and the need for additional study, since there are few reported cases.
format Online
Article
Text
id pubmed-6986969
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Korean Society of Pathologists and the Korean Society for Cytopathology
record_format MEDLINE/PubMed
spelling pubmed-69869692020-02-05 Morule-like features in pulmonary adenocarcinoma associated with epidermal growth factor receptor mutations: two case reports with targeted next-generation sequencing analysis Lee, Yoo Jin Oh, Harim Kim, Eojin Ahn, Bokyung Lee, Jeong Hyeon Lee, Youngseok Chae, Yang Seok Kim, Chul Hwan J Pathol Transl Med Case Study Morules, or morule-like features, can be identified in benign and malignant lesions in various organs. Morular features are unusual in pulmonary adenocarcinoma cases with only 26 cases reported to date. Here, we describe two cases of pulmonary adenocarcinoma with morule-like features in Korean women. One patient had a non-mucinous-type adenocarcinoma in situ and the other had an acinarpredominant adenocarcinoma with a micropapillary component. Both patients showed multiple intra-alveolar, nodular, whorled proliferative foci composed of atypical spindle cells with eosinophilic cytoplasm. Targeted next-generation sequencing was performed on DNA extracted from formalin-fixed paraffin-embedded samples of the tumors. Results showed unusual epidermal growth factor receptor (EGFR) mutations, which are associated with drug resistance to EGFR tyrosine kinase inhibitors, revealing the importance of identifying morule-like features in pulmonary adenocarcinoma and the need for additional study, since there are few reported cases. The Korean Society of Pathologists and the Korean Society for Cytopathology 2020-01 2019-11-01 /pmc/articles/PMC6986969/ /pubmed/31674165 http://dx.doi.org/10.4132/jptm.2019.09.30 Text en © The Korean Society of Pathologists/The Korean Society for Cytopathology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Study
Lee, Yoo Jin
Oh, Harim
Kim, Eojin
Ahn, Bokyung
Lee, Jeong Hyeon
Lee, Youngseok
Chae, Yang Seok
Kim, Chul Hwan
Morule-like features in pulmonary adenocarcinoma associated with epidermal growth factor receptor mutations: two case reports with targeted next-generation sequencing analysis
title Morule-like features in pulmonary adenocarcinoma associated with epidermal growth factor receptor mutations: two case reports with targeted next-generation sequencing analysis
title_full Morule-like features in pulmonary adenocarcinoma associated with epidermal growth factor receptor mutations: two case reports with targeted next-generation sequencing analysis
title_fullStr Morule-like features in pulmonary adenocarcinoma associated with epidermal growth factor receptor mutations: two case reports with targeted next-generation sequencing analysis
title_full_unstemmed Morule-like features in pulmonary adenocarcinoma associated with epidermal growth factor receptor mutations: two case reports with targeted next-generation sequencing analysis
title_short Morule-like features in pulmonary adenocarcinoma associated with epidermal growth factor receptor mutations: two case reports with targeted next-generation sequencing analysis
title_sort morule-like features in pulmonary adenocarcinoma associated with epidermal growth factor receptor mutations: two case reports with targeted next-generation sequencing analysis
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986969/
https://www.ncbi.nlm.nih.gov/pubmed/31674165
http://dx.doi.org/10.4132/jptm.2019.09.30
work_keys_str_mv AT leeyoojin morulelikefeaturesinpulmonaryadenocarcinomaassociatedwithepidermalgrowthfactorreceptormutationstwocasereportswithtargetednextgenerationsequencinganalysis
AT ohharim morulelikefeaturesinpulmonaryadenocarcinomaassociatedwithepidermalgrowthfactorreceptormutationstwocasereportswithtargetednextgenerationsequencinganalysis
AT kimeojin morulelikefeaturesinpulmonaryadenocarcinomaassociatedwithepidermalgrowthfactorreceptormutationstwocasereportswithtargetednextgenerationsequencinganalysis
AT ahnbokyung morulelikefeaturesinpulmonaryadenocarcinomaassociatedwithepidermalgrowthfactorreceptormutationstwocasereportswithtargetednextgenerationsequencinganalysis
AT leejeonghyeon morulelikefeaturesinpulmonaryadenocarcinomaassociatedwithepidermalgrowthfactorreceptormutationstwocasereportswithtargetednextgenerationsequencinganalysis
AT leeyoungseok morulelikefeaturesinpulmonaryadenocarcinomaassociatedwithepidermalgrowthfactorreceptormutationstwocasereportswithtargetednextgenerationsequencinganalysis
AT chaeyangseok morulelikefeaturesinpulmonaryadenocarcinomaassociatedwithepidermalgrowthfactorreceptormutationstwocasereportswithtargetednextgenerationsequencinganalysis
AT kimchulhwan morulelikefeaturesinpulmonaryadenocarcinomaassociatedwithepidermalgrowthfactorreceptormutationstwocasereportswithtargetednextgenerationsequencinganalysis