Terminological and Epistemological Issues in Current Memory Research

A number of observations in recent years demonstrates that across all levels of organization, memory is inherently fluid. On the cognitive-behavioral level, the innocent act of remembering can irrevocably alter the contents of established long-term memories, while the content of dormant long-term memories that is deemed irrelevant, superfluous, or limiting may be pragmatically erased or suppressed. On the cellular level, the proteins implementing the molecular alterations underpinning memories are in a constant state of flux, with proteins being turned over, translocated, reconfigured, substituted, and replaced. Yet, the general perception of memory, and the words used to describe it, suggest a static system characterized by the goal of preserving records of past experiences with high fidelity, in contrast to the reality of an inherently adaptive system purposed to enable survival in a changing world with a pragmatic disregard for the fate of acquired memories. Here, we examine present memory terminology and how it corresponds to our actual understanding of the molecules, cells, and systems underlying memory. We will identify where terms lead us astray and line out possible ways to reform memory nomenclature to better fit the true nature of memory as we begin to know it.