Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release

Tooth defect and tooth loss are common clinical diseases in stomatology. Compared with the traditional oral restoration treatment, tooth regeneration has unique advantages and is currently the focus of oral biomedical research. It is known that dozens of cytokines/growth factors and other bioactive...

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Autores principales: Huang, Delan, Ren, Jianhan, Li, Runze, Guan, Chenyu, Feng, Zhicai, Bao, Baicheng, Wang, Weicai, Zhou, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987083/
https://www.ncbi.nlm.nih.gov/pubmed/31834583
http://dx.doi.org/10.1007/s12015-019-09940-0
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author Huang, Delan
Ren, Jianhan
Li, Runze
Guan, Chenyu
Feng, Zhicai
Bao, Baicheng
Wang, Weicai
Zhou, Chen
author_facet Huang, Delan
Ren, Jianhan
Li, Runze
Guan, Chenyu
Feng, Zhicai
Bao, Baicheng
Wang, Weicai
Zhou, Chen
author_sort Huang, Delan
collection PubMed
description Tooth defect and tooth loss are common clinical diseases in stomatology. Compared with the traditional oral restoration treatment, tooth regeneration has unique advantages and is currently the focus of oral biomedical research. It is known that dozens of cytokines/growth factors and other bioactive factors are expressed in a spatial-temporal pattern during tooth development. On the other hand, the technology for spatial-temporal control of drug release has been intensively studied and well developed recently, making control release of these bioactive factors mimicking spatial-temporal pattern more feasible than ever for the purpose of tooth regeneration. This article reviews the research progress on the tooth development and discusses the future of tooth regeneration in the context of spatial-temporal release of developmental factors.
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spelling pubmed-69870832020-02-07 Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release Huang, Delan Ren, Jianhan Li, Runze Guan, Chenyu Feng, Zhicai Bao, Baicheng Wang, Weicai Zhou, Chen Stem Cell Rev Rep Article Tooth defect and tooth loss are common clinical diseases in stomatology. Compared with the traditional oral restoration treatment, tooth regeneration has unique advantages and is currently the focus of oral biomedical research. It is known that dozens of cytokines/growth factors and other bioactive factors are expressed in a spatial-temporal pattern during tooth development. On the other hand, the technology for spatial-temporal control of drug release has been intensively studied and well developed recently, making control release of these bioactive factors mimicking spatial-temporal pattern more feasible than ever for the purpose of tooth regeneration. This article reviews the research progress on the tooth development and discusses the future of tooth regeneration in the context of spatial-temporal release of developmental factors. Springer US 2019-12-13 2020 /pmc/articles/PMC6987083/ /pubmed/31834583 http://dx.doi.org/10.1007/s12015-019-09940-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Huang, Delan
Ren, Jianhan
Li, Runze
Guan, Chenyu
Feng, Zhicai
Bao, Baicheng
Wang, Weicai
Zhou, Chen
Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release
title Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release
title_full Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release
title_fullStr Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release
title_full_unstemmed Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release
title_short Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release
title_sort tooth regeneration: insights from tooth development and spatial-temporal control of bioactive drug release
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987083/
https://www.ncbi.nlm.nih.gov/pubmed/31834583
http://dx.doi.org/10.1007/s12015-019-09940-0
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