Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter

Poly(ADP-ribose) polymerase 1 (PARP1) regulates gene transcription in addition to functioning as a DNA repair factor. Forkhead box O1 (FoxO1) is a transcription factor involved in extensive biological processes. Here, we report that PARP1 binds to two separate motifs on the FoxO1 promoter and repres...

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Detalles Bibliográficos
Autores principales: Tian, Yu-Nan, Chen, Hua-Dong, Tian, Chang-Qing, Wang, Ying-Qing, Miao, Ze-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987093/
https://www.ncbi.nlm.nih.gov/pubmed/31992690
http://dx.doi.org/10.1038/s41419-020-2265-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987093/
https://www.ncbi.nlm.nih.gov/pubmed/31992690
http://dx.doi.org/10.1038/s41419-020-2265-y

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