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Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter
Poly(ADP-ribose) polymerase 1 (PARP1) regulates gene transcription in addition to functioning as a DNA repair factor. Forkhead box O1 (FoxO1) is a transcription factor involved in extensive biological processes. Here, we report that PARP1 binds to two separate motifs on the FoxO1 promoter and repres...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987093/ https://www.ncbi.nlm.nih.gov/pubmed/31992690 http://dx.doi.org/10.1038/s41419-020-2265-y |