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The mechanism of how CD95/Fas activates the Type I IFN/STAT1 axis, driving cancer stemness in breast cancer

CD95/Fas is an apoptosis inducing death receptor. However, it also has multiple nonapoptotic activities that are tumorigenic. Chronic stimulation of CD95 on breast cancer cells can increase their cancer initiating capacity through activation of a type I interferon (IFN-I)/STAT1 pathway when caspases...

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Detalles Bibliográficos
Autores principales:	Qadir, Abdul S., Stults, Austin M., Murmann, Andrea E., Peter, Marcus E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987111/ https://www.ncbi.nlm.nih.gov/pubmed/31992798 http://dx.doi.org/10.1038/s41598-020-58211-3

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