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Investigation of post-therapeutic image-based thyroid dosimetry using quantitative SPECT/CT, iodine biokinetics, and the MIRD’s voxel S values in Graves’ disease

BACKGROUND: Before radioiodine therapy for Graves’ disease, the estimated thyroid-absorbed dose is calculated based on various clinical parameters. However, the actual accumulation of iodine in the thyroid during radioiodine therapy is not determined. We validated the feasibility of post-therapeutic...

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Autores principales: Fujita, Naotoshi, Koshiba, Yumiko, Abe, Shinji, Kato, Katsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987275/
https://www.ncbi.nlm.nih.gov/pubmed/31993828
http://dx.doi.org/10.1186/s40658-020-0274-7
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author Fujita, Naotoshi
Koshiba, Yumiko
Abe, Shinji
Kato, Katsuhiko
author_facet Fujita, Naotoshi
Koshiba, Yumiko
Abe, Shinji
Kato, Katsuhiko
author_sort Fujita, Naotoshi
collection PubMed
description BACKGROUND: Before radioiodine therapy for Graves’ disease, the estimated thyroid-absorbed dose is calculated based on various clinical parameters. However, the actual accumulation of iodine in the thyroid during radioiodine therapy is not determined. We validated the feasibility of post-therapeutic image-based thyroid dosimetry through quantitative single-photon emission computed tomography (SPECT) imaging and thyroid biokinetics and expanding the Medical Internal Radiation Dose Committee’s (MIRD) voxel dosimetry guidelines. METHODS: Forty-three patients with Graves’ disease who underwent radioiodine therapy were chosen as subjects for this retrospective analysis. We acquired patients’ SPECT images 24 h after oral administration. SPECT images were quantified using system volume sensitivity to calculate time-integrated activity coefficients on a voxel basis. Absorbed dose was obtained by convolving MIRD guideline voxel S values with time-integrated activity coefficients. To determine accuracy, we compared the results obtained using the post-therapeutic image-based absorbed-dose method (D̅(image,PVC)) with absorbed doses calculated using the method described by the European Association of Nuclear Medicine (pre-therapeutic method; D(EANM)). RESULTS: Using image-based dosimetry as post-therapeutic dosimetry, we visualized the local accumulation and absorbed dose distribution of iodine in the thyroid. Furthermore, we determined a strong correlation (Pearson’s correlation coefficient = 0.89) between both dosimetries, using the regression equation: D̅(image,PVC) = 0.94 × D(EANM) + 1.35. CONCLUSION: Post-therapeutic image-based doses absorbed in the thyroid resembled those of pre-therapeutic EANM method-based absorbed doses. Additionally, the post-therapeutic image-based method had the advantage of visualizing thyroid iodine distribution, thus determining local dose distributions at the time of treatment. From these points, we propose that post-therapeutic image-based dosimetry could provide an alternative to standard pre-therapeutic dosimetry to evaluate dose response.
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spelling pubmed-69872752020-02-11 Investigation of post-therapeutic image-based thyroid dosimetry using quantitative SPECT/CT, iodine biokinetics, and the MIRD’s voxel S values in Graves’ disease Fujita, Naotoshi Koshiba, Yumiko Abe, Shinji Kato, Katsuhiko EJNMMI Phys Original Research BACKGROUND: Before radioiodine therapy for Graves’ disease, the estimated thyroid-absorbed dose is calculated based on various clinical parameters. However, the actual accumulation of iodine in the thyroid during radioiodine therapy is not determined. We validated the feasibility of post-therapeutic image-based thyroid dosimetry through quantitative single-photon emission computed tomography (SPECT) imaging and thyroid biokinetics and expanding the Medical Internal Radiation Dose Committee’s (MIRD) voxel dosimetry guidelines. METHODS: Forty-three patients with Graves’ disease who underwent radioiodine therapy were chosen as subjects for this retrospective analysis. We acquired patients’ SPECT images 24 h after oral administration. SPECT images were quantified using system volume sensitivity to calculate time-integrated activity coefficients on a voxel basis. Absorbed dose was obtained by convolving MIRD guideline voxel S values with time-integrated activity coefficients. To determine accuracy, we compared the results obtained using the post-therapeutic image-based absorbed-dose method (D̅(image,PVC)) with absorbed doses calculated using the method described by the European Association of Nuclear Medicine (pre-therapeutic method; D(EANM)). RESULTS: Using image-based dosimetry as post-therapeutic dosimetry, we visualized the local accumulation and absorbed dose distribution of iodine in the thyroid. Furthermore, we determined a strong correlation (Pearson’s correlation coefficient = 0.89) between both dosimetries, using the regression equation: D̅(image,PVC) = 0.94 × D(EANM) + 1.35. CONCLUSION: Post-therapeutic image-based doses absorbed in the thyroid resembled those of pre-therapeutic EANM method-based absorbed doses. Additionally, the post-therapeutic image-based method had the advantage of visualizing thyroid iodine distribution, thus determining local dose distributions at the time of treatment. From these points, we propose that post-therapeutic image-based dosimetry could provide an alternative to standard pre-therapeutic dosimetry to evaluate dose response. Springer International Publishing 2020-01-28 /pmc/articles/PMC6987275/ /pubmed/31993828 http://dx.doi.org/10.1186/s40658-020-0274-7 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Fujita, Naotoshi
Koshiba, Yumiko
Abe, Shinji
Kato, Katsuhiko
Investigation of post-therapeutic image-based thyroid dosimetry using quantitative SPECT/CT, iodine biokinetics, and the MIRD’s voxel S values in Graves’ disease
title Investigation of post-therapeutic image-based thyroid dosimetry using quantitative SPECT/CT, iodine biokinetics, and the MIRD’s voxel S values in Graves’ disease
title_full Investigation of post-therapeutic image-based thyroid dosimetry using quantitative SPECT/CT, iodine biokinetics, and the MIRD’s voxel S values in Graves’ disease
title_fullStr Investigation of post-therapeutic image-based thyroid dosimetry using quantitative SPECT/CT, iodine biokinetics, and the MIRD’s voxel S values in Graves’ disease
title_full_unstemmed Investigation of post-therapeutic image-based thyroid dosimetry using quantitative SPECT/CT, iodine biokinetics, and the MIRD’s voxel S values in Graves’ disease
title_short Investigation of post-therapeutic image-based thyroid dosimetry using quantitative SPECT/CT, iodine biokinetics, and the MIRD’s voxel S values in Graves’ disease
title_sort investigation of post-therapeutic image-based thyroid dosimetry using quantitative spect/ct, iodine biokinetics, and the mird’s voxel s values in graves’ disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987275/
https://www.ncbi.nlm.nih.gov/pubmed/31993828
http://dx.doi.org/10.1186/s40658-020-0274-7
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