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Conversion of Glucose to 5-Hydroxymethylfurfural in a Microreactor
5-hydroxymethylfurfural (5-HMF) is one of the key bio-based platform chemicals for the production of high-value chemicals and fuels. The conventional production of 5-HMF from biomass is confronted by the relatively low yield and high production cost. In this work, the enhancement of a continuous cat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987406/ https://www.ncbi.nlm.nih.gov/pubmed/32039159 http://dx.doi.org/10.3389/fchem.2019.00951 |
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author | Tongtummachat, Tiprawee Akkarawatkhoosith, Nattee Kaewchada, Amaraporn Jaree, Attasak |
author_facet | Tongtummachat, Tiprawee Akkarawatkhoosith, Nattee Kaewchada, Amaraporn Jaree, Attasak |
author_sort | Tongtummachat, Tiprawee |
collection | PubMed |
description | 5-hydroxymethylfurfural (5-HMF) is one of the key bio-based platform chemicals for the production of high-value chemicals and fuels. The conventional production of 5-HMF from biomass is confronted by the relatively low yield and high production cost. In this work, the enhancement of a continuous catalytic synthesis of 5-HMF in a biphasic-dispersed flow reactor was proposed. Glucose, hydrochloric acid, and methyl isobutyl ketone (MIBK) were used as a low-cost raw material, catalyst, and organic solvent, respectively. The main factors (reaction temperature, residence time, solvent amount, and catalyst concentration) affecting the yield and selectivity of 5-HMF were studied. The 5-HMF yield of 81.7% and 5-HMF selectivity of 89.8% were achieved at the residence time of 3 min, reaction temperature of 180°C, the volumetric flow rate of aqueous phase to organic phase of 0.5:1, and catalyst concentration of 0.15 M. The yield and selectivity of 5-HMF obtained from the biphasic system were significantly higher than that obtained from the single phase system. The superior 5-HMF production in our system in terms of operating conditions was presented when compared to the literature data. Furthermore, the continuous process for removing HCl from the aqueous product was also proposed. |
format | Online Article Text |
id | pubmed-6987406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69874062020-02-07 Conversion of Glucose to 5-Hydroxymethylfurfural in a Microreactor Tongtummachat, Tiprawee Akkarawatkhoosith, Nattee Kaewchada, Amaraporn Jaree, Attasak Front Chem Chemistry 5-hydroxymethylfurfural (5-HMF) is one of the key bio-based platform chemicals for the production of high-value chemicals and fuels. The conventional production of 5-HMF from biomass is confronted by the relatively low yield and high production cost. In this work, the enhancement of a continuous catalytic synthesis of 5-HMF in a biphasic-dispersed flow reactor was proposed. Glucose, hydrochloric acid, and methyl isobutyl ketone (MIBK) were used as a low-cost raw material, catalyst, and organic solvent, respectively. The main factors (reaction temperature, residence time, solvent amount, and catalyst concentration) affecting the yield and selectivity of 5-HMF were studied. The 5-HMF yield of 81.7% and 5-HMF selectivity of 89.8% were achieved at the residence time of 3 min, reaction temperature of 180°C, the volumetric flow rate of aqueous phase to organic phase of 0.5:1, and catalyst concentration of 0.15 M. The yield and selectivity of 5-HMF obtained from the biphasic system were significantly higher than that obtained from the single phase system. The superior 5-HMF production in our system in terms of operating conditions was presented when compared to the literature data. Furthermore, the continuous process for removing HCl from the aqueous product was also proposed. Frontiers Media S.A. 2020-01-22 /pmc/articles/PMC6987406/ /pubmed/32039159 http://dx.doi.org/10.3389/fchem.2019.00951 Text en Copyright © 2020 Tongtummachat, Akkarawatkhoosith, Kaewchada and Jaree. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Tongtummachat, Tiprawee Akkarawatkhoosith, Nattee Kaewchada, Amaraporn Jaree, Attasak Conversion of Glucose to 5-Hydroxymethylfurfural in a Microreactor |
title | Conversion of Glucose to 5-Hydroxymethylfurfural in a Microreactor |
title_full | Conversion of Glucose to 5-Hydroxymethylfurfural in a Microreactor |
title_fullStr | Conversion of Glucose to 5-Hydroxymethylfurfural in a Microreactor |
title_full_unstemmed | Conversion of Glucose to 5-Hydroxymethylfurfural in a Microreactor |
title_short | Conversion of Glucose to 5-Hydroxymethylfurfural in a Microreactor |
title_sort | conversion of glucose to 5-hydroxymethylfurfural in a microreactor |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987406/ https://www.ncbi.nlm.nih.gov/pubmed/32039159 http://dx.doi.org/10.3389/fchem.2019.00951 |
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