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Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression

BACKGROUND: Anxious depression (AD), which is generally recognized as a common clinical subtype of major depressive disorder (MDD), holds distinctive features compared with unanxious depression (UAD). However, the neural mechanism of AD still remains unrevealed. To give insight to it, we compared re...

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Autores principales: Zhao, Peng, Yan, Rui, Wang, Xinyi, Geng, Jiting, Chattun, Mohammad Ridwan, Wang, Qiang, Yao, Zhijian, Lu, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987425/
https://www.ncbi.nlm.nih.gov/pubmed/32038329
http://dx.doi.org/10.3389/fpsyt.2019.00994
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author Zhao, Peng
Yan, Rui
Wang, Xinyi
Geng, Jiting
Chattun, Mohammad Ridwan
Wang, Qiang
Yao, Zhijian
Lu, Qing
author_facet Zhao, Peng
Yan, Rui
Wang, Xinyi
Geng, Jiting
Chattun, Mohammad Ridwan
Wang, Qiang
Yao, Zhijian
Lu, Qing
author_sort Zhao, Peng
collection PubMed
description BACKGROUND: Anxious depression (AD), which is generally recognized as a common clinical subtype of major depressive disorder (MDD), holds distinctive features compared with unanxious depression (UAD). However, the neural mechanism of AD still remains unrevealed. To give insight to it, we compared resting-state functional magnetic resonance amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) between AD and UAD patients. METHOD: The data were collected from 60 AD patients, 38 UAD patients, and 60 matched healthy controls. The ALFF and seed-based FC were examined. Pearson correlations were computed between ALFF/FC and clinical measures. RESULTS: In Comparison with the UAD group, the ALFF value of the right orbital part of middle frontal gyrus (RO-MFG) decreased in AD group. Specifically, the ALFF values of the RO-MFG were negatively correlated with retardation factor scores in AD group (r = -0.376, p = 0.003). CONCLUSIONS: AD patients exhibited disturbed intrinsic brain function compared with UAD patients. The decreased activity of the RO-MFG is indicative of the alterations involved in the neural basis of AD.
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spelling pubmed-69874252020-02-07 Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression Zhao, Peng Yan, Rui Wang, Xinyi Geng, Jiting Chattun, Mohammad Ridwan Wang, Qiang Yao, Zhijian Lu, Qing Front Psychiatry Psychiatry BACKGROUND: Anxious depression (AD), which is generally recognized as a common clinical subtype of major depressive disorder (MDD), holds distinctive features compared with unanxious depression (UAD). However, the neural mechanism of AD still remains unrevealed. To give insight to it, we compared resting-state functional magnetic resonance amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) between AD and UAD patients. METHOD: The data were collected from 60 AD patients, 38 UAD patients, and 60 matched healthy controls. The ALFF and seed-based FC were examined. Pearson correlations were computed between ALFF/FC and clinical measures. RESULTS: In Comparison with the UAD group, the ALFF value of the right orbital part of middle frontal gyrus (RO-MFG) decreased in AD group. Specifically, the ALFF values of the RO-MFG were negatively correlated with retardation factor scores in AD group (r = -0.376, p = 0.003). CONCLUSIONS: AD patients exhibited disturbed intrinsic brain function compared with UAD patients. The decreased activity of the RO-MFG is indicative of the alterations involved in the neural basis of AD. Frontiers Media S.A. 2020-01-22 /pmc/articles/PMC6987425/ /pubmed/32038329 http://dx.doi.org/10.3389/fpsyt.2019.00994 Text en Copyright © 2020 Zhao, Yan, Wang, Geng, Chattun, Wang, Yao and Lu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Zhao, Peng
Yan, Rui
Wang, Xinyi
Geng, Jiting
Chattun, Mohammad Ridwan
Wang, Qiang
Yao, Zhijian
Lu, Qing
Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression
title Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression
title_full Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression
title_fullStr Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression
title_full_unstemmed Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression
title_short Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression
title_sort reduced resting state neural activity in the right orbital part of middle frontal gyrus in anxious depression
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987425/
https://www.ncbi.nlm.nih.gov/pubmed/32038329
http://dx.doi.org/10.3389/fpsyt.2019.00994
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