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Effects of Gait Treatment With a Single-Leg Hybrid Assistive Limb System After Acute Stroke: A Non-randomized Clinical Trial

We hypothesized that a single-leg version of the Hybrid Assistive Limb (HAL) system could improve the gait and physical function of patients with hemiparesis following a stroke. In this pilot study, we therefore compared the efficacy of HAL-based gait training with that of conventional gait training...

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Autores principales: Watanabe, Hiroki, Marushima, Aiki, Kadone, Hideki, Ueno, Tomoyuki, Shimizu, Yukiyo, Kubota, Shigeki, Hino, Tenyu, Sato, Masayuki, Ito, Yoshiro, Hayakawa, Mikito, Tsurushima, Hideo, Takada, Tomoya, Tsukada, Atsuro, Fujimori, Hiroyuki, Sato, Naoaki, Maruo, Kazushi, Kawamoto, Hiroaki, Hada, Yasushi, Yamazaki, Masashi, Sankai, Yoshiyuki, Ishikawa, Eiichi, Matsumaru, Yuji, Matsumura, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987474/
https://www.ncbi.nlm.nih.gov/pubmed/32038125
http://dx.doi.org/10.3389/fnins.2019.01389
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author Watanabe, Hiroki
Marushima, Aiki
Kadone, Hideki
Ueno, Tomoyuki
Shimizu, Yukiyo
Kubota, Shigeki
Hino, Tenyu
Sato, Masayuki
Ito, Yoshiro
Hayakawa, Mikito
Tsurushima, Hideo
Takada, Tomoya
Tsukada, Atsuro
Fujimori, Hiroyuki
Sato, Naoaki
Maruo, Kazushi
Kawamoto, Hiroaki
Hada, Yasushi
Yamazaki, Masashi
Sankai, Yoshiyuki
Ishikawa, Eiichi
Matsumaru, Yuji
Matsumura, Akira
author_facet Watanabe, Hiroki
Marushima, Aiki
Kadone, Hideki
Ueno, Tomoyuki
Shimizu, Yukiyo
Kubota, Shigeki
Hino, Tenyu
Sato, Masayuki
Ito, Yoshiro
Hayakawa, Mikito
Tsurushima, Hideo
Takada, Tomoya
Tsukada, Atsuro
Fujimori, Hiroyuki
Sato, Naoaki
Maruo, Kazushi
Kawamoto, Hiroaki
Hada, Yasushi
Yamazaki, Masashi
Sankai, Yoshiyuki
Ishikawa, Eiichi
Matsumaru, Yuji
Matsumura, Akira
author_sort Watanabe, Hiroki
collection PubMed
description We hypothesized that a single-leg version of the Hybrid Assistive Limb (HAL) system could improve the gait and physical function of patients with hemiparesis following a stroke. In this pilot study, we therefore compared the efficacy of HAL-based gait training with that of conventional gait training (CGT) in patients with acute stroke. Patients admitted to the participating university hospital were assigned to the HAL group, whereas those admitted to outside teaching hospitals under the same rehabilitation program who did not use the HAL were assigned to the control group. Over 3 weeks, all participants completed nine 20 min sessions of gait training, using either HAL (i.e., the single-leg version of HAL on the paretic side) or conventional methods (i.e., walking aids and gait orthoses). Outcome measures were evaluated before and after the nine training sessions. The Functional Ambulation Category (FAC) was the primary outcome measure, but the following secondary outcome measures were also assessed: National Institutes of Health Stroke Scale, Fugl–Meyer Assessment (Lower Extremity), comfortable walking speed, step length, cadence, 6-min walk distance, Barthel Index, and Functional Independence Measure. In total, 22 post-stroke participants completed the clinical trial: 12 in the HAL group and 10 in the CGT group. No serious adverse events occurred in either group. The HAL group showed significant improvement in FAC after nine sessions when compared with the CGT group (P = 0.014). However, secondary outcomes did not differ significantly between the groups. Our results demonstrate that HAL-based gait therapy may improve independent walking in patients with acute stroke hemiplegia who are dependent on ambulatory assistance. A larger-scale randomized controlled trial is needed to clarify the effectiveness of single-leg HAL therapy. Clinical Trial Registration: UMIN Clinical Trials Registry, identifier UMIN000022410.
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spelling pubmed-69874742020-02-07 Effects of Gait Treatment With a Single-Leg Hybrid Assistive Limb System After Acute Stroke: A Non-randomized Clinical Trial Watanabe, Hiroki Marushima, Aiki Kadone, Hideki Ueno, Tomoyuki Shimizu, Yukiyo Kubota, Shigeki Hino, Tenyu Sato, Masayuki Ito, Yoshiro Hayakawa, Mikito Tsurushima, Hideo Takada, Tomoya Tsukada, Atsuro Fujimori, Hiroyuki Sato, Naoaki Maruo, Kazushi Kawamoto, Hiroaki Hada, Yasushi Yamazaki, Masashi Sankai, Yoshiyuki Ishikawa, Eiichi Matsumaru, Yuji Matsumura, Akira Front Neurosci Neuroscience We hypothesized that a single-leg version of the Hybrid Assistive Limb (HAL) system could improve the gait and physical function of patients with hemiparesis following a stroke. In this pilot study, we therefore compared the efficacy of HAL-based gait training with that of conventional gait training (CGT) in patients with acute stroke. Patients admitted to the participating university hospital were assigned to the HAL group, whereas those admitted to outside teaching hospitals under the same rehabilitation program who did not use the HAL were assigned to the control group. Over 3 weeks, all participants completed nine 20 min sessions of gait training, using either HAL (i.e., the single-leg version of HAL on the paretic side) or conventional methods (i.e., walking aids and gait orthoses). Outcome measures were evaluated before and after the nine training sessions. The Functional Ambulation Category (FAC) was the primary outcome measure, but the following secondary outcome measures were also assessed: National Institutes of Health Stroke Scale, Fugl–Meyer Assessment (Lower Extremity), comfortable walking speed, step length, cadence, 6-min walk distance, Barthel Index, and Functional Independence Measure. In total, 22 post-stroke participants completed the clinical trial: 12 in the HAL group and 10 in the CGT group. No serious adverse events occurred in either group. The HAL group showed significant improvement in FAC after nine sessions when compared with the CGT group (P = 0.014). However, secondary outcomes did not differ significantly between the groups. Our results demonstrate that HAL-based gait therapy may improve independent walking in patients with acute stroke hemiplegia who are dependent on ambulatory assistance. A larger-scale randomized controlled trial is needed to clarify the effectiveness of single-leg HAL therapy. Clinical Trial Registration: UMIN Clinical Trials Registry, identifier UMIN000022410. Frontiers Media S.A. 2020-01-22 /pmc/articles/PMC6987474/ /pubmed/32038125 http://dx.doi.org/10.3389/fnins.2019.01389 Text en Copyright © 2020 Watanabe, Marushima, Kadone, Ueno, Shimizu, Kubota, Hino, Sato, Ito, Hayakawa, Tsurushima, Takada, Tsukada, Fujimori, Sato, Maruo, Kawamoto, Hada, Yamazaki, Sankai, Ishikawa, Matsumaru and Matsumura. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Watanabe, Hiroki
Marushima, Aiki
Kadone, Hideki
Ueno, Tomoyuki
Shimizu, Yukiyo
Kubota, Shigeki
Hino, Tenyu
Sato, Masayuki
Ito, Yoshiro
Hayakawa, Mikito
Tsurushima, Hideo
Takada, Tomoya
Tsukada, Atsuro
Fujimori, Hiroyuki
Sato, Naoaki
Maruo, Kazushi
Kawamoto, Hiroaki
Hada, Yasushi
Yamazaki, Masashi
Sankai, Yoshiyuki
Ishikawa, Eiichi
Matsumaru, Yuji
Matsumura, Akira
Effects of Gait Treatment With a Single-Leg Hybrid Assistive Limb System After Acute Stroke: A Non-randomized Clinical Trial
title Effects of Gait Treatment With a Single-Leg Hybrid Assistive Limb System After Acute Stroke: A Non-randomized Clinical Trial
title_full Effects of Gait Treatment With a Single-Leg Hybrid Assistive Limb System After Acute Stroke: A Non-randomized Clinical Trial
title_fullStr Effects of Gait Treatment With a Single-Leg Hybrid Assistive Limb System After Acute Stroke: A Non-randomized Clinical Trial
title_full_unstemmed Effects of Gait Treatment With a Single-Leg Hybrid Assistive Limb System After Acute Stroke: A Non-randomized Clinical Trial
title_short Effects of Gait Treatment With a Single-Leg Hybrid Assistive Limb System After Acute Stroke: A Non-randomized Clinical Trial
title_sort effects of gait treatment with a single-leg hybrid assistive limb system after acute stroke: a non-randomized clinical trial
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987474/
https://www.ncbi.nlm.nih.gov/pubmed/32038125
http://dx.doi.org/10.3389/fnins.2019.01389
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