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Role of Sfrps in cardiovascular disease
Secreted frizzled-related proteins (Sfrps) are a family of secreted proteins that bind extracellularly to Wnt ligands and frizzled receptors. This binding modulates the Wnt signaling cascade, and Sfrps interact with their corresponding receptors. Sfrps are thought to play an important role in the pa...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987486/ https://www.ncbi.nlm.nih.gov/pubmed/32064070 http://dx.doi.org/10.1177/2040622320901990 |
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author | Huang, Anqing Huang, Yuli |
author_facet | Huang, Anqing Huang, Yuli |
author_sort | Huang, Anqing |
collection | PubMed |
description | Secreted frizzled-related proteins (Sfrps) are a family of secreted proteins that bind extracellularly to Wnt ligands and frizzled receptors. This binding modulates the Wnt signaling cascade, and Sfrps interact with their corresponding receptors. Sfrps are thought to play an important role in the pathological mechanism of cardiac disease such as myocardial infarction, cardiac remodeling, and heart failure. However, the overall role of Sfrps in cardiac disease is unknown. Some members of the Sfrps family modulate cellular apoptosis, angiogenesis, differentiation, the inflammatory process, and cardiac remodeling. In this review, we summarize the evidence of Sfrps association with cardiac disease. We also discuss how multiple mechanisms may underlie Sfrps being involved in such diverse pathologies. |
format | Online Article Text |
id | pubmed-6987486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-69874862020-02-14 Role of Sfrps in cardiovascular disease Huang, Anqing Huang, Yuli Ther Adv Chronic Dis Prevention and Treatment of Cardiovascular Disease Secreted frizzled-related proteins (Sfrps) are a family of secreted proteins that bind extracellularly to Wnt ligands and frizzled receptors. This binding modulates the Wnt signaling cascade, and Sfrps interact with their corresponding receptors. Sfrps are thought to play an important role in the pathological mechanism of cardiac disease such as myocardial infarction, cardiac remodeling, and heart failure. However, the overall role of Sfrps in cardiac disease is unknown. Some members of the Sfrps family modulate cellular apoptosis, angiogenesis, differentiation, the inflammatory process, and cardiac remodeling. In this review, we summarize the evidence of Sfrps association with cardiac disease. We also discuss how multiple mechanisms may underlie Sfrps being involved in such diverse pathologies. SAGE Publications 2020-01-28 /pmc/articles/PMC6987486/ /pubmed/32064070 http://dx.doi.org/10.1177/2040622320901990 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Prevention and Treatment of Cardiovascular Disease Huang, Anqing Huang, Yuli Role of Sfrps in cardiovascular disease |
title | Role of Sfrps in cardiovascular disease |
title_full | Role of Sfrps in cardiovascular disease |
title_fullStr | Role of Sfrps in cardiovascular disease |
title_full_unstemmed | Role of Sfrps in cardiovascular disease |
title_short | Role of Sfrps in cardiovascular disease |
title_sort | role of sfrps in cardiovascular disease |
topic | Prevention and Treatment of Cardiovascular Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987486/ https://www.ncbi.nlm.nih.gov/pubmed/32064070 http://dx.doi.org/10.1177/2040622320901990 |
work_keys_str_mv | AT huanganqing roleofsfrpsincardiovasculardisease AT huangyuli roleofsfrpsincardiovasculardisease |