AMD3100 Attenuates Post-Traumatic Osteoarthritis by Maintaining Transforming Growth Factor-β1-Induced Expression of Tissue Inhibitor of Metalloproteinase-3 via the Phosphatidylinositol 3-Kinase/Akt Pathway

AMD3100 is a small-molecule inhibitor of the C-X-C motif chemokine ligand 12/C-X-C chemokine receptor type 4 (CXCL12/CXCR4) axis, while its role in aggrecan metabolism is unclear. We hypothesized that the AMD3100 modulates the transforming growth factor-β1 (TGF-β1)-induced expression of tissue inhib...

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Detalles Bibliográficos
Autores principales: Lu, Weiwei, He, Zhiyi, Shi, Jia, Wang, Zhenggang, Wu, Wei, Liu, Jian, Kang, Hao, Li, Feng, Liang, Shuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987846/
https://www.ncbi.nlm.nih.gov/pubmed/32038242
http://dx.doi.org/10.3389/fphar.2019.01554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987846/
https://www.ncbi.nlm.nih.gov/pubmed/32038242
http://dx.doi.org/10.3389/fphar.2019.01554

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