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AMD3100 Attenuates Post-Traumatic Osteoarthritis by Maintaining Transforming Growth Factor-β1-Induced Expression of Tissue Inhibitor of Metalloproteinase-3 via the Phosphatidylinositol 3-Kinase/Akt Pathway
AMD3100 is a small-molecule inhibitor of the C-X-C motif chemokine ligand 12/C-X-C chemokine receptor type 4 (CXCL12/CXCR4) axis, while its role in aggrecan metabolism is unclear. We hypothesized that the AMD3100 modulates the transforming growth factor-β1 (TGF-β1)-induced expression of tissue inhib...
Autores principales: | Lu, Weiwei, He, Zhiyi, Shi, Jia, Wang, Zhenggang, Wu, Wei, Liu, Jian, Kang, Hao, Li, Feng, Liang, Shuang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987846/ https://www.ncbi.nlm.nih.gov/pubmed/32038242 http://dx.doi.org/10.3389/fphar.2019.01554 |
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