Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019

From September to October 2019, seven patients colonised or infected with a ceftazidime-avibactam (CZA)-resistant Klebsiella pneumoniae carbapenemase (KPC)-2-producing K. pneumoniae were detected in two intensive care units of a Greek general hospital. The outbreak strain was sequence type (ST)147 a...

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Autores principales: Galani, Irene, Karaiskos, Ilias, Souli, Maria, Papoutsaki, Vassiliki, Galani, Lamprini, Gkoufa, Aikaterini, Antoniadou, Anastasia, Giamarellou, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988274/
https://www.ncbi.nlm.nih.gov/pubmed/31992391
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.3.2000028
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author Galani, Irene
Karaiskos, Ilias
Souli, Maria
Papoutsaki, Vassiliki
Galani, Lamprini
Gkoufa, Aikaterini
Antoniadou, Anastasia
Giamarellou, Helen
author_facet Galani, Irene
Karaiskos, Ilias
Souli, Maria
Papoutsaki, Vassiliki
Galani, Lamprini
Gkoufa, Aikaterini
Antoniadou, Anastasia
Giamarellou, Helen
author_sort Galani, Irene
collection PubMed
description From September to October 2019, seven patients colonised or infected with a ceftazidime-avibactam (CZA)-resistant Klebsiella pneumoniae carbapenemase (KPC)-2-producing K. pneumoniae were detected in two intensive care units of a Greek general hospital. The outbreak strain was sequence type (ST)147 and co-produced KPC-2 and the novel plasmid-borne Vietnamese extended-spectrum β-lactamase (VEB)-25 harbouring a K234R substitution associated with CZA resistance. Epidemiological investigations revealed that the resistance was probably acquired by horizontal transmission independently from previous CZA exposure.
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spelling pubmed-69882742020-02-06 Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019 Galani, Irene Karaiskos, Ilias Souli, Maria Papoutsaki, Vassiliki Galani, Lamprini Gkoufa, Aikaterini Antoniadou, Anastasia Giamarellou, Helen Euro Surveill Rapid Communication From September to October 2019, seven patients colonised or infected with a ceftazidime-avibactam (CZA)-resistant Klebsiella pneumoniae carbapenemase (KPC)-2-producing K. pneumoniae were detected in two intensive care units of a Greek general hospital. The outbreak strain was sequence type (ST)147 and co-produced KPC-2 and the novel plasmid-borne Vietnamese extended-spectrum β-lactamase (VEB)-25 harbouring a K234R substitution associated with CZA resistance. Epidemiological investigations revealed that the resistance was probably acquired by horizontal transmission independently from previous CZA exposure. European Centre for Disease Prevention and Control (ECDC) 2020-01-23 /pmc/articles/PMC6988274/ /pubmed/31992391 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.3.2000028 Text en This article is copyright of the authors or their affiliated institutions, 2020. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Galani, Irene
Karaiskos, Ilias
Souli, Maria
Papoutsaki, Vassiliki
Galani, Lamprini
Gkoufa, Aikaterini
Antoniadou, Anastasia
Giamarellou, Helen
Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019
title Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019
title_full Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019
title_fullStr Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019
title_full_unstemmed Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019
title_short Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019
title_sort outbreak of kpc-2-producing klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a veb-1-mutant (veb-25), greece, september to october 2019
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988274/
https://www.ncbi.nlm.nih.gov/pubmed/31992391
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.3.2000028
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