Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol

BACKGROUND: Celastrol is a promising anti-obesity agent that acts as a sensitizer of the protein hormone leptin. Despite its potent activity, a sustainable source of celastrol and celastrol derivatives for further pharmacological studies is lacking. RESULTS: To elucidate the celastrol biosynthetic p...

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Detalles Bibliográficos
Autores principales: Hansen, Nikolaj L., Miettinen, Karel, Zhao, Yong, Ignea, Codruta, Andreadelli, Aggeliki, Raadam, Morten H., Makris, Antonios M., Møller, Birger L., Stærk, Dan, Bak, Søren, Kampranis, Sotirios C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988343/
https://www.ncbi.nlm.nih.gov/pubmed/31992268
http://dx.doi.org/10.1186/s12934-020-1284-9

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