Ultrasensitive recognition of AP sites in DNA at the single-cell level: one molecular rotor sequentially self-regulated to form multiple different stable conformations

The AP site is a primary form of DNA damage. Its presence alters the genetic structure and eventually causes malignant diseases. AP sites generally present a high-speed dynamic change in the DNA sequence. Thus, precisely recognizing AP sites is difficult, especially at the single-cell level. To addr...

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Detalles Bibliográficos
Autores principales: Feng, Beidou, Wang, Kui, Yang, Yonggang, Wang, Ge, Zhang, Hua, Liu, Yufang, Jiang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988597/
https://www.ncbi.nlm.nih.gov/pubmed/32110326
http://dx.doi.org/10.1039/c9sc04140k

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