Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations

A bottom-up self-assembly approach is developed for the synthesis of ABC type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal...

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Detalles Bibliográficos
Autores principales: Fu, Jianye, Gu, Zhengying, Liu, Yang, Zhang, Jun, Song, Hao, Yang, Yannan, Yang, Yang, Noonan, Owen, Tang, Jie, Yu, Chengzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988604/
https://www.ncbi.nlm.nih.gov/pubmed/32110328
http://dx.doi.org/10.1039/c9sc02961c
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author Fu, Jianye
Gu, Zhengying
Liu, Yang
Zhang, Jun
Song, Hao
Yang, Yannan
Yang, Yang
Noonan, Owen
Tang, Jie
Yu, Chengzhong
author_facet Fu, Jianye
Gu, Zhengying
Liu, Yang
Zhang, Jun
Song, Hao
Yang, Yannan
Yang, Yang
Noonan, Owen
Tang, Jie
Yu, Chengzhong
author_sort Fu, Jianye
collection PubMed
description A bottom-up self-assembly approach is developed for the synthesis of ABC type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an in vitro epithelial monolayer model mimicking the human intestinal epithelium.
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spelling pubmed-69886042020-02-27 Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations Fu, Jianye Gu, Zhengying Liu, Yang Zhang, Jun Song, Hao Yang, Yannan Yang, Yang Noonan, Owen Tang, Jie Yu, Chengzhong Chem Sci Chemistry A bottom-up self-assembly approach is developed for the synthesis of ABC type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an in vitro epithelial monolayer model mimicking the human intestinal epithelium. Royal Society of Chemistry 2019-09-19 /pmc/articles/PMC6988604/ /pubmed/32110328 http://dx.doi.org/10.1039/c9sc02961c Text en This journal is © The Royal Society of Chemistry 2019 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Fu, Jianye
Gu, Zhengying
Liu, Yang
Zhang, Jun
Song, Hao
Yang, Yannan
Yang, Yang
Noonan, Owen
Tang, Jie
Yu, Chengzhong
Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations
title Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations
title_full Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations
title_fullStr Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations
title_full_unstemmed Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations
title_short Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations
title_sort bottom-up self-assembly of heterotrimeric nanoparticles and their secondary janus generations
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988604/
https://www.ncbi.nlm.nih.gov/pubmed/32110328
http://dx.doi.org/10.1039/c9sc02961c
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