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Anti-Cancer Effects of Panax ginseng Berry Polysaccharides via Activation of Immune-Related Cells

Panax ginseng has long been used as natural medicine and health food all over the world. Cancer is a major cause of death worldwide and its prognosis likely depends on the immune system during tumor treatment. In this study, ginseng berry polysaccharides were evaluated for their immunostimulant and...

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Autores principales: Lee, Dae-Young, Park, Chan Woong, Lee, Sue Jung, Park, Hye-Ryung, Kim, Su Hwan, Son, Seung-U, Park, Jiyong, Shin, Kwang-Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988799/
https://www.ncbi.nlm.nih.gov/pubmed/32038228
http://dx.doi.org/10.3389/fphar.2019.01411
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author Lee, Dae-Young
Park, Chan Woong
Lee, Sue Jung
Park, Hye-Ryung
Kim, Su Hwan
Son, Seung-U
Park, Jiyong
Shin, Kwang-Soon
author_facet Lee, Dae-Young
Park, Chan Woong
Lee, Sue Jung
Park, Hye-Ryung
Kim, Su Hwan
Son, Seung-U
Park, Jiyong
Shin, Kwang-Soon
author_sort Lee, Dae-Young
collection PubMed
description Panax ginseng has long been used as natural medicine and health food all over the world. Cancer is a major cause of death worldwide and its prognosis likely depends on the immune system during tumor treatment. In this study, ginseng berry polysaccharides were evaluated for their immunostimulant and anti-cancer effects. Ginseng berry polysaccharide portion (GBPP) was used to investigate its effects on anti-complementary activity, peritoneal macrophage activation, and natural killer (NK) cell cytotoxicity. Moreover, both intravenous (i.v.) and oral administration of GBPP prior to B16-BL6 melanoma implantation in mice was evaluated. GBPP significantly increased the anti-complementary activity and cytokine production including interleukin (IL)-6, IL-12, and tumor necrosis factor (TNF)-α, dose-dependently. Splenocytes obtained after i.v. administration of GBPP showed cytolytic activity in Yac-1 cells in proportion to the E/T ratio. In addition, GBPP enhanced the production of interferon (IFN)-γ and granzyme B of NK cells. For the experimental lung cancer, compared with control mice, GBPP delivered by i.v. suppressed cancer by 48% at 100 μg/mouse, while a 37% reduction was achieved by oral administration. Deficient of NK cells in animal model demonstrated that the anti-cancer effect of GBPP was through NK cell activation. Results of this study suggest that ginseng berry polysaccharides, owing to their modulation of the immune response, can be a potential curative applicant for the prevention and treatment of tumors.
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spelling pubmed-69887992020-02-07 Anti-Cancer Effects of Panax ginseng Berry Polysaccharides via Activation of Immune-Related Cells Lee, Dae-Young Park, Chan Woong Lee, Sue Jung Park, Hye-Ryung Kim, Su Hwan Son, Seung-U Park, Jiyong Shin, Kwang-Soon Front Pharmacol Pharmacology Panax ginseng has long been used as natural medicine and health food all over the world. Cancer is a major cause of death worldwide and its prognosis likely depends on the immune system during tumor treatment. In this study, ginseng berry polysaccharides were evaluated for their immunostimulant and anti-cancer effects. Ginseng berry polysaccharide portion (GBPP) was used to investigate its effects on anti-complementary activity, peritoneal macrophage activation, and natural killer (NK) cell cytotoxicity. Moreover, both intravenous (i.v.) and oral administration of GBPP prior to B16-BL6 melanoma implantation in mice was evaluated. GBPP significantly increased the anti-complementary activity and cytokine production including interleukin (IL)-6, IL-12, and tumor necrosis factor (TNF)-α, dose-dependently. Splenocytes obtained after i.v. administration of GBPP showed cytolytic activity in Yac-1 cells in proportion to the E/T ratio. In addition, GBPP enhanced the production of interferon (IFN)-γ and granzyme B of NK cells. For the experimental lung cancer, compared with control mice, GBPP delivered by i.v. suppressed cancer by 48% at 100 μg/mouse, while a 37% reduction was achieved by oral administration. Deficient of NK cells in animal model demonstrated that the anti-cancer effect of GBPP was through NK cell activation. Results of this study suggest that ginseng berry polysaccharides, owing to their modulation of the immune response, can be a potential curative applicant for the prevention and treatment of tumors. Frontiers Media S.A. 2019-11-26 /pmc/articles/PMC6988799/ /pubmed/32038228 http://dx.doi.org/10.3389/fphar.2019.01411 Text en Copyright © 2019 Lee, Park, Lee, Park, Kim, Son, Park and Shin http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Lee, Dae-Young
Park, Chan Woong
Lee, Sue Jung
Park, Hye-Ryung
Kim, Su Hwan
Son, Seung-U
Park, Jiyong
Shin, Kwang-Soon
Anti-Cancer Effects of Panax ginseng Berry Polysaccharides via Activation of Immune-Related Cells
title Anti-Cancer Effects of Panax ginseng Berry Polysaccharides via Activation of Immune-Related Cells
title_full Anti-Cancer Effects of Panax ginseng Berry Polysaccharides via Activation of Immune-Related Cells
title_fullStr Anti-Cancer Effects of Panax ginseng Berry Polysaccharides via Activation of Immune-Related Cells
title_full_unstemmed Anti-Cancer Effects of Panax ginseng Berry Polysaccharides via Activation of Immune-Related Cells
title_short Anti-Cancer Effects of Panax ginseng Berry Polysaccharides via Activation of Immune-Related Cells
title_sort anti-cancer effects of panax ginseng berry polysaccharides via activation of immune-related cells
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988799/
https://www.ncbi.nlm.nih.gov/pubmed/32038228
http://dx.doi.org/10.3389/fphar.2019.01411
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