An Easy and Efficient Strategy for the Enhancement of Epothilone Production Mediated by TALE-TF and CRISPR/dcas9 Systems in Sorangium cellulosum

Epothilones are a kind of macrolides with strong cytotoxicity toward cancer cells and relatively lower side effects compared with taxol. Epothilone B derivate ixabepilone has been used for the clinical treatment of advanced breast cancer. However, the low yield of epothilones and the difficulty in t...

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Detalles Bibliográficos
Autores principales: Ye, Wei, Liu, Taomei, Zhu, Muzi, Zhang, Weimin, Huang, Zilei, Li, Saini, Li, Haohua, Kong, Yali, Chen, Yuchan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988809/
https://www.ncbi.nlm.nih.gov/pubmed/32039165
http://dx.doi.org/10.3389/fbioe.2019.00334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988809/
https://www.ncbi.nlm.nih.gov/pubmed/32039165
http://dx.doi.org/10.3389/fbioe.2019.00334

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