Escherichia coli O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea

No outbreaks caused by Escherichia coli–producing heat-labile enterotoxin LT2 have been reported to date. Here, we revealed that the E. coli O8:H8 strains isolated from patients in 2 independent diarrhea outbreaks were negative for any known virulence determinants in routine microbiological tests, w...

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Detalles Bibliográficos
Autores principales: Ishimaru, Kai, Sasaki, Mari, Narimatsu, Hiroshi, Arimizu, Yoko, Gotoh, Yasuhiro, Nakamura, Keiji, Hayashi, Tetsuya, Ogura, Yoshitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988837/
https://www.ncbi.nlm.nih.gov/pubmed/32016129
http://dx.doi.org/10.1093/ofid/ofaa021
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author Ishimaru, Kai
Sasaki, Mari
Narimatsu, Hiroshi
Arimizu, Yoko
Gotoh, Yasuhiro
Nakamura, Keiji
Hayashi, Tetsuya
Ogura, Yoshitoshi
author_facet Ishimaru, Kai
Sasaki, Mari
Narimatsu, Hiroshi
Arimizu, Yoko
Gotoh, Yasuhiro
Nakamura, Keiji
Hayashi, Tetsuya
Ogura, Yoshitoshi
author_sort Ishimaru, Kai
collection PubMed
description No outbreaks caused by Escherichia coli–producing heat-labile enterotoxin LT2 have been reported to date. Here, we revealed that the E. coli O8:H8 strains isolated from patients in 2 independent diarrhea outbreaks were negative for any known virulence determinants in routine microbiological tests, were very closely related, and carried a prophage-encoded gene for a novel LT2 variant (LT2d) and the genes for colonization factor antigen III. We also showed that LT2d has a cytotonic activity similar to LT1. These data indicate the importance of E. coli strains producing LT2d as a human pathogen.
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spelling pubmed-69888372020-02-03 Escherichia coli O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea Ishimaru, Kai Sasaki, Mari Narimatsu, Hiroshi Arimizu, Yoko Gotoh, Yasuhiro Nakamura, Keiji Hayashi, Tetsuya Ogura, Yoshitoshi Open Forum Infect Dis Brief Report No outbreaks caused by Escherichia coli–producing heat-labile enterotoxin LT2 have been reported to date. Here, we revealed that the E. coli O8:H8 strains isolated from patients in 2 independent diarrhea outbreaks were negative for any known virulence determinants in routine microbiological tests, were very closely related, and carried a prophage-encoded gene for a novel LT2 variant (LT2d) and the genes for colonization factor antigen III. We also showed that LT2d has a cytotonic activity similar to LT1. These data indicate the importance of E. coli strains producing LT2d as a human pathogen. Oxford University Press 2020-01-14 /pmc/articles/PMC6988837/ /pubmed/32016129 http://dx.doi.org/10.1093/ofid/ofaa021 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Ishimaru, Kai
Sasaki, Mari
Narimatsu, Hiroshi
Arimizu, Yoko
Gotoh, Yasuhiro
Nakamura, Keiji
Hayashi, Tetsuya
Ogura, Yoshitoshi
Escherichia coli O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea
title Escherichia coli O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea
title_full Escherichia coli O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea
title_fullStr Escherichia coli O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea
title_full_unstemmed Escherichia coli O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea
title_short Escherichia coli O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea
title_sort escherichia coli o8:h8 carrying a novel variant of the heat-labile enterotoxin lt2 gene caused outbreaks of diarrhea
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988837/
https://www.ncbi.nlm.nih.gov/pubmed/32016129
http://dx.doi.org/10.1093/ofid/ofaa021
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