Cargando…

Metabolic syndrome diminishes insulin-induced Akt activation and causes a redistribution of Akt-interacting proteins in cardiomyocytes

Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors, with insulin resistance as a critical component for its development. Insulin signaling in the heart leads to Akt (also known as PKB) activation, a serine/threonine protein kinase, which regulates cardiac glucose metabolism and g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Landa-Galvan, Huguet V., Rios-Castro, Emmanuel, Romero-Garcia, Tatiana, Rueda, Angelica, Olivares-Reyes, Jesus Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988918/ https://www.ncbi.nlm.nih.gov/pubmed/31995605 http://dx.doi.org/10.1371/journal.pone.0228115

Ejemplares similares

SUN-080 Diminished Akt Activation and Interaction with 14-3-3ζ is Associated with Insulin Resistance in Cardiomyocytes of Metabolic Syndrome Rats
por: Landa-Galván, Huguet, et al.
Publicado: (2019)

MicroRNA‐495‐3p diminishes doxorubicin‐induced cardiotoxicity through activating AKT
por: Meng, Jun, et al.
Publicado: (2022)

Angiotensin II Inhibits Insulin Receptor Signaling in Adipose Cells
por: Gutierrez-Rodelo, Citlaly, et al.
Publicado: (2022)

The female syndecan-4(−/−) heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels
por: Støle, Thea Parsberg, et al.
Publicado: (2022)

Antiangiogenic Treatment Diminishes Renal Injury and Dysfunction via Regulation of Local AKT in Early Experimental Diabetes
por: Bai, Xiaoyan, et al.
Publicado: (2014)

ADAM23 in Cardiomyocyte Inhibits Cardiac Hypertrophy by Targeting FAK‐AKT Signaling
por: Xiang, Mei, et al.
Publicado: (2018)

Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 Signaling Pathway
por: Parra, Valentina, et al.
Publicado: (2014)

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
por: Fernández-Miranda, Gaudencio, et al.
Publicado: (2019)

Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle
por: Zheng, Xiaohua, et al.
Publicado: (2016)

Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry
por: Cheshenko, Natalia, et al.
Publicado: (2018)

The Insulin Receptor Substrate 2 Mediates the Action of Insulin on HeLa Cell Migration via the PI3K/Akt Signaling Pathway
por: Martínez Báez, Anabel, et al.
Publicado: (2023)

Correction: Antiangiogenic Treatment Diminishes Renal Injury and Dysfunction via Regulation of Local AKT in Early Experimental Diabetes
Publicado: (2014)

Labdane diterpenes protect against anoxia/reperfusion injury in cardiomyocytes: involvement of AKT activation
por: Cuadrado, I, et al.
Publicado: (2011)

Pyrrolidinyl caffeamide against ischemia/reperfusion injury in cardiomyocytes through AMPK/AKT pathways
por: Lee, Shih-Yi, et al.
Publicado: (2015)

Excitotoxic glutamate causes neuronal insulin resistance by inhibiting insulin receptor/Akt/mTOR pathway
por: Pomytkin, Igor, et al.
Publicado: (2019)

Akt1 and -2 inhibition diminishes terminal differentiation and enhances central memory CD8(+) T-cell proliferation and survival
por: Abu Eid, Rasha, et al.
Publicado: (2015)

GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis
por: Srivastava, Ritesh K., et al.
Publicado: (2014)

Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3β signaling
por: Chen, Xiao-Yu, et al.
Publicado: (2017)

Inhibition of AKT with the Orally Active Allosteric AKT Inhibitor, MK-2206, Sensitizes Endometrial Cancer Cells to Progestin
por: Pant, Alok, et al.
Publicado: (2012)

Coculture with hematopoietic stem cells protects cardiomyocytes against apoptosis via paracrine activation of AKT
por: Rosenberg, Mark, et al.
Publicado: (2012)

Downregulation of Cypher induces apoptosis in cardiomyocytes via Akt/p38 MAPK signaling pathway
por: Xuan, Tianming, et al.
Publicado: (2020)

Resveratrol Targets AKT1 to Inhibit Inflammasome Activation in Cardiomyocytes Under Acute Sympathetic Stress
por: Wang, Rui, et al.
Publicado: (2022)

Major vault protein attenuates cardiomyocyte injury in doxorubicin-induced cardiomyopathy through activating AKT
por: Qi, Yu, et al.
Publicado: (2022)

LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway
por: Zhou, Huixing, et al.
Publicado: (2022)

β(3)-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes
por: Schobesberger, Sophie, et al.
Publicado: (2020)

Cinnamaldehyde and Curcumin Prime Akt2 for Insulin-Stimulated Activation
por: Urasaki, Yasuyo, et al.
Publicado: (2022)

Surface redistribution of 125I-insulin in cultured human lymphocytes
Publicado: (1981)

Sequential exocytosis of insulin granules is associated with redistribution of SNAP25
por: Takahashi, Noriko, et al.
Publicado: (2004)

All Akt Isoforms (Akt1, Akt2, Akt3) Are Involved in Normal Hearing, but Only Akt2 and Akt3 Are Involved in Auditory Hair Cell Survival in the Mammalian Inner Ear
por: Brand, Yves, et al.
Publicado: (2015)

AKT-induced lncRNA VAL promotes EMT-independent metastasis through diminishing Trim16-dependent Vimentin degradation
por: Tian, Han, et al.
Publicado: (2020)

Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes
por: Roberts, David J., et al.
Publicado: (2013)

AKIP1, a Cardiac Hypertrophy Induced Protein that Stimulates Cardiomyocyte Growth via the Akt Pathway
por: Yu, Hongjuan, et al.
Publicado: (2013)

FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT
por: Zhang, Xin, et al.
Publicado: (2019)

Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes
por: Tan, Shi-Xiong, et al.
Publicado: (2012)

Potassium content diminishes in infected cells of Medicago truncatula nodules due to the mislocation of channels MtAKT1 and MtSKOR/GORK
por: Fedorova, Elena E, et al.
Publicado: (2020)

Akt Is S-Palmitoylated: A New Layer of Regulation for Akt
por: Blaustein, Matías, et al.
Publicado: (2021)

The Increased Expression of Regulator of G-Protein Signaling 2 (RGS2) Inhibits Insulin-Induced Akt Phosphorylation and Is Associated with Uncontrolled Glycemia in Patients with Type 2 Diabetes
por: Vazquez-Jimenez, J. Gustavo, et al.
Publicado: (2021)

Cyclophilin A Protects Cardiomyocytes against Hypoxia/Reoxygenation-Induced Apoptosis via the AKT/Nox2 Pathway
por: Cheng, Fuyu, et al.
Publicado: (2019)

Activation of PI3Kγ/Akt pathway increases cardiomyocyte HMGB1 expression in diabetic environment
por: Song, Jia, et al.
Publicado: (2016)

Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3K/AKT/mTOR Pathway
por: Yu, Wei, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_22n3cnfkqc37sp8vdehf663s2r