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Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction

Neurofibrillary tangles likely cause neurodegeneration in Alzheimer's disease (AD). We demonstrate that the CX3CL1 C-terminal domain can upregulate neurogenesis, which may ameliorate neurodegeneration. Here we generated transgenic (Tg-CX3CL1) mice by overexpressing CX3CL1 in neurons. Tg-CX3CL1...

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Detalles Bibliográficos
Autores principales:	Fan, Qingyuan, He, Wanxia, Gayen, Manoshi, Benoit, Marc Robert, Luo, Xiaoyang, Hu, Xiangyou, Yan, Riqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989010/ https://www.ncbi.nlm.nih.gov/pubmed/31822518 http://dx.doi.org/10.1523/JNEUROSCI.1333-19.2019

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