Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Activation of cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in antiviral responses to many DNA viruses. Sensing of cytosolic DNA by cGAS results in synthesis of the endogenous second messenger cGAMP that activates stimulator of interferon genes (STING) in infected cells. Critically, c...

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Detalles Bibliográficos
Autores principales: Pépin, Geneviève, De Nardo, Dominic, Rootes, Christina L., Ullah, Tomalika R., Al-Asmari, Sumaiah S., Balka, Katherine R., Li, Hong-Mei, Quinn, Kylie M., Moghaddas, Fiona, Chappaz, Stephane, Kile, Benjamin T., Morand, Eric F., Masters, Seth L., Stewart, Cameron R., Williams, Bryan R. G., Gantier, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989113/
https://www.ncbi.nlm.nih.gov/pubmed/31992625
http://dx.doi.org/10.1128/mBio.03187-19

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