Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity

To uncover the genetic basis of anthracycline-induced cardiotoxicity (AIC), we recently established a genetic suppressor screening strategy in zebrafish. Here, we report the molecular and cellular nature of GBT0419, a salutary modifier mutant that affects retinoid x receptor alpha a (rxraa). We show...

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Detalles Bibliográficos
Autores principales: Ma, Xiao, Zhu, Ping, Ding, Yonghe, Zhang, Hong, Qiu, Qi, Dvornikov, Alexey V., Wang, Zheng, Kim, Maengjo, Wang, Yong, Lowerison, Matthew, Yu, Yue, Norton, Nadine, Herrmann, Joerg, Ekker, Stephen C., Hsiai, Tzung K., Lin, Xueying, Xu, Xiaolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989136/
https://www.ncbi.nlm.nih.gov/pubmed/32064346
http://dx.doi.org/10.1126/sciadv.aay2939

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