Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers

Women harboring heterozygous germline mutations of BRCA2 have a 50 to 80% risk of developing breast cancer, yet the pathogenesis of these cancers is poorly understood. To reveal early steps in BRCA2-associated carcinogenesis, we analyzed sorted cell populations from freshly-isolated, non-cancerous b...

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Detalles Bibliográficos
Autores principales: Karaayvaz-Yildirim, Mihriban, Silberman, Rebecca E., Langenbucher, Adam, Saladi, Srinivas Vinod, Ross, Kenneth N., Zarcaro, Elena, Desmond, Andrea, Yildirim, Murat, Vivekanandan, Varunika, Ravichandran, Hiranmayi, Mylavagnanam, Ravindra, Specht, Michelle C., Ramaswamy, Sridhar, Lawrence, Michael, Amon, Angelika, Ellisen, Leif W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989139/
https://www.ncbi.nlm.nih.gov/pubmed/32064343
http://dx.doi.org/10.1126/sciadv.aay2611

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