Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

Perforin-2 (MPEG1) is thought to enable the killing of invading microbes engulfed by macrophages and other phagocytes, forming pores in their membranes. Loss of perforin-2 renders individual phagocytes and whole organisms significantly more susceptible to bacterial pathogens. Here, we reveal the mec...

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Detalles Bibliográficos
Autores principales: Ni, Tao, Jiao, Fang, Yu, Xiulian, Aden, Saša, Ginger, Lucy, Williams, Sophie I., Bai, Fangfang, Pražák, Vojtěch, Karia, Dimple, Stansfeld, Phillip, Zhang, Peijun, Munson, George, Anderluh, Gregor, Scheuring, Simon, Gilbert, Robert J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989145/
https://www.ncbi.nlm.nih.gov/pubmed/32064340
http://dx.doi.org/10.1126/sciadv.aax8286

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