Simultaneous quantification of ticagrelor and its active metabolite, AR-C124910XX, in human plasma by liquid chromatography-tandem mass spectrometry: Applications in steady-state pharmacokinetics in patients

A sensitive and simple liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous quantification of ticagrelor and its active metabolite, AR-C124910XX from 50 µL human plasma using tolbutamide as an internal standard as per regulatory guidelines. Analytes...

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Detalles Bibliográficos
Autores principales: Chae, Soon Uk, Min, Kyoung Lok, Lee, Chae Bin, Huang, Zhouchi, Chang, Min Jung, Bae, Soo Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Clinical Pharmacology and Therapeutics 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989238/
https://www.ncbi.nlm.nih.gov/pubmed/32055590
http://dx.doi.org/10.12793/tcp.2019.27.3.98

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