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Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies
The intricate interplay between the immune system and microbes is an essential part of the physiological homeostasis in health and disease. Immunological recognition of commensal microbes, such as bacterial species resident in the gut or lung as well as dormant viral species, i.e., cytomegalovirus (...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989410/ https://www.ncbi.nlm.nih.gov/pubmed/32039196 http://dx.doi.org/10.3389/fcell.2019.00362 |
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author | Lérias, Joana R. Paraschoudi, Georgia de Sousa, Eric Martins, João Condeço, Carolina Figueiredo, Nuno Carvalho, Carlos Dodoo, Ernest Castillo-Martin, Mireia Beltrán, Antonio Ligeiro, Dário Rao, Martin Zumla, Alimuddin Maeurer, Markus |
author_facet | Lérias, Joana R. Paraschoudi, Georgia de Sousa, Eric Martins, João Condeço, Carolina Figueiredo, Nuno Carvalho, Carlos Dodoo, Ernest Castillo-Martin, Mireia Beltrán, Antonio Ligeiro, Dário Rao, Martin Zumla, Alimuddin Maeurer, Markus |
author_sort | Lérias, Joana R. |
collection | PubMed |
description | The intricate interplay between the immune system and microbes is an essential part of the physiological homeostasis in health and disease. Immunological recognition of commensal microbes, such as bacterial species resident in the gut or lung as well as dormant viral species, i.e., cytomegalovirus (CMV) or Epstein-Barr virus (EBV), in combination with a balanced immune regulation, is central to achieve immune-protection. Emerging evidence suggests that immune responses primed to guard against commensal microbes may cause unexpected pathological outcomes, e.g., chronic inflammation and/or malignant transformation. Furthermore, translocation of immune cells from one anatomical compartment to another, i.e., the gut-lung axis via the lymphatics or blood has been identified as an important factor in perpetrating systemic inflammation, tissue destruction, as well as modulating host-protective immune responses. We present in this review immune response patterns to pathogenic as well as non-pathogenic microbes and how these immune-recognition profiles affect local immune responses or malignant transformation. We discuss personalized immunological therapies which, directly or indirectly, target host biological pathways modulated by antimicrobial immune responses. |
format | Online Article Text |
id | pubmed-6989410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69894102020-02-07 Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies Lérias, Joana R. Paraschoudi, Georgia de Sousa, Eric Martins, João Condeço, Carolina Figueiredo, Nuno Carvalho, Carlos Dodoo, Ernest Castillo-Martin, Mireia Beltrán, Antonio Ligeiro, Dário Rao, Martin Zumla, Alimuddin Maeurer, Markus Front Cell Dev Biol Cell and Developmental Biology The intricate interplay between the immune system and microbes is an essential part of the physiological homeostasis in health and disease. Immunological recognition of commensal microbes, such as bacterial species resident in the gut or lung as well as dormant viral species, i.e., cytomegalovirus (CMV) or Epstein-Barr virus (EBV), in combination with a balanced immune regulation, is central to achieve immune-protection. Emerging evidence suggests that immune responses primed to guard against commensal microbes may cause unexpected pathological outcomes, e.g., chronic inflammation and/or malignant transformation. Furthermore, translocation of immune cells from one anatomical compartment to another, i.e., the gut-lung axis via the lymphatics or blood has been identified as an important factor in perpetrating systemic inflammation, tissue destruction, as well as modulating host-protective immune responses. We present in this review immune response patterns to pathogenic as well as non-pathogenic microbes and how these immune-recognition profiles affect local immune responses or malignant transformation. We discuss personalized immunological therapies which, directly or indirectly, target host biological pathways modulated by antimicrobial immune responses. Frontiers Media S.A. 2020-01-23 /pmc/articles/PMC6989410/ /pubmed/32039196 http://dx.doi.org/10.3389/fcell.2019.00362 Text en Copyright © 2020 Lérias, Paraschoudi, de Sousa, Martins, Condeço, Figueiredo, Carvalho, Dodoo, Castillo-Martin, Beltrán, Ligeiro, Rao, Zumla and Maeurer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Lérias, Joana R. Paraschoudi, Georgia de Sousa, Eric Martins, João Condeço, Carolina Figueiredo, Nuno Carvalho, Carlos Dodoo, Ernest Castillo-Martin, Mireia Beltrán, Antonio Ligeiro, Dário Rao, Martin Zumla, Alimuddin Maeurer, Markus Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies |
title | Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies |
title_full | Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies |
title_fullStr | Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies |
title_full_unstemmed | Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies |
title_short | Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies |
title_sort | microbes as master immunomodulators: immunopathology, cancer and personalized immunotherapies |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989410/ https://www.ncbi.nlm.nih.gov/pubmed/32039196 http://dx.doi.org/10.3389/fcell.2019.00362 |
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