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Amphetamine Derivatives as Monoamine Oxidase Inhibitors
Amphetamine and its derivatives exhibit a wide range of pharmacological activities, including psychostimulant, hallucinogenic, entactogenic, anorectic, or antidepressant effects. The mechanisms of action underlying these effects are usually related to the ability of the different amphetamines to int...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989591/ https://www.ncbi.nlm.nih.gov/pubmed/32038257 http://dx.doi.org/10.3389/fphar.2019.01590 |
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author | Reyes-Parada, Miguel Iturriaga-Vasquez, Patricio Cassels, Bruce K. |
author_facet | Reyes-Parada, Miguel Iturriaga-Vasquez, Patricio Cassels, Bruce K. |
author_sort | Reyes-Parada, Miguel |
collection | PubMed |
description | Amphetamine and its derivatives exhibit a wide range of pharmacological activities, including psychostimulant, hallucinogenic, entactogenic, anorectic, or antidepressant effects. The mechanisms of action underlying these effects are usually related to the ability of the different amphetamines to interact with diverse monoamine transporters or receptors. Moreover, many of these compounds are also potent and selective monoamine oxidase inhibitors. In the present work, we review how structural modifications on the aromatic ring, the amino group and/or the aliphatic side chain of the parent scaffold, modulate the enzyme inhibitory properties of hundreds of amphetamine derivatives. Furthermore, we discuss how monoamine oxidase inhibition might influence the pharmacology of these compounds. |
format | Online Article Text |
id | pubmed-6989591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69895912020-02-07 Amphetamine Derivatives as Monoamine Oxidase Inhibitors Reyes-Parada, Miguel Iturriaga-Vasquez, Patricio Cassels, Bruce K. Front Pharmacol Pharmacology Amphetamine and its derivatives exhibit a wide range of pharmacological activities, including psychostimulant, hallucinogenic, entactogenic, anorectic, or antidepressant effects. The mechanisms of action underlying these effects are usually related to the ability of the different amphetamines to interact with diverse monoamine transporters or receptors. Moreover, many of these compounds are also potent and selective monoamine oxidase inhibitors. In the present work, we review how structural modifications on the aromatic ring, the amino group and/or the aliphatic side chain of the parent scaffold, modulate the enzyme inhibitory properties of hundreds of amphetamine derivatives. Furthermore, we discuss how monoamine oxidase inhibition might influence the pharmacology of these compounds. Frontiers Media S.A. 2020-01-23 /pmc/articles/PMC6989591/ /pubmed/32038257 http://dx.doi.org/10.3389/fphar.2019.01590 Text en Copyright © 2020 Reyes-Parada, Iturriaga-Vasquez and Cassels http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Reyes-Parada, Miguel Iturriaga-Vasquez, Patricio Cassels, Bruce K. Amphetamine Derivatives as Monoamine Oxidase Inhibitors |
title | Amphetamine Derivatives as Monoamine Oxidase Inhibitors |
title_full | Amphetamine Derivatives as Monoamine Oxidase Inhibitors |
title_fullStr | Amphetamine Derivatives as Monoamine Oxidase Inhibitors |
title_full_unstemmed | Amphetamine Derivatives as Monoamine Oxidase Inhibitors |
title_short | Amphetamine Derivatives as Monoamine Oxidase Inhibitors |
title_sort | amphetamine derivatives as monoamine oxidase inhibitors |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989591/ https://www.ncbi.nlm.nih.gov/pubmed/32038257 http://dx.doi.org/10.3389/fphar.2019.01590 |
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