The various routes to functional regeneration in the central nervous system

The axolotl is a type of Mexican salamander with astonishing regenerative capacity(1). In our recent paper, we identified a signaling heterodimer that is formed directly after injury in the glial cells adjacent to the injury in axolotls. The c-Fos and JunB genes forming this heterodimer are not uniq...

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Autor principal: Echeverri, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989630/
https://www.ncbi.nlm.nih.gov/pubmed/31996777
http://dx.doi.org/10.1038/s42003-020-0773-z
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author Echeverri, Karen
author_facet Echeverri, Karen
author_sort Echeverri, Karen
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description The axolotl is a type of Mexican salamander with astonishing regenerative capacity(1). In our recent paper, we identified a signaling heterodimer that is formed directly after injury in the glial cells adjacent to the injury in axolotls. The c-Fos and JunB genes forming this heterodimer are not unique to animals with high regenerative capacity but they are present in humans too. In this paper I propose perspectives on molecular control of regeneration and future directions that need to be taken to advance our understanding of regeneration at a molecular level.
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spelling pubmed-69896302020-02-05 The various routes to functional regeneration in the central nervous system Echeverri, Karen Commun Biol Comment The axolotl is a type of Mexican salamander with astonishing regenerative capacity(1). In our recent paper, we identified a signaling heterodimer that is formed directly after injury in the glial cells adjacent to the injury in axolotls. The c-Fos and JunB genes forming this heterodimer are not unique to animals with high regenerative capacity but they are present in humans too. In this paper I propose perspectives on molecular control of regeneration and future directions that need to be taken to advance our understanding of regeneration at a molecular level. Nature Publishing Group UK 2020-01-29 /pmc/articles/PMC6989630/ /pubmed/31996777 http://dx.doi.org/10.1038/s42003-020-0773-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Echeverri, Karen
The various routes to functional regeneration in the central nervous system
title The various routes to functional regeneration in the central nervous system
title_full The various routes to functional regeneration in the central nervous system
title_fullStr The various routes to functional regeneration in the central nervous system
title_full_unstemmed The various routes to functional regeneration in the central nervous system
title_short The various routes to functional regeneration in the central nervous system
title_sort various routes to functional regeneration in the central nervous system
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989630/
https://www.ncbi.nlm.nih.gov/pubmed/31996777
http://dx.doi.org/10.1038/s42003-020-0773-z
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