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Increased circulating galectin-1 levels are associated with the progression of kidney function decline in patients undergoing coronary angiography

Galectin-1 modulates acute and chronic inflammation, and is associated with glucose homeostasis and chronic renal disease. Whether the serum galectin-1 level can predict short-term and long-term renal outcomes after contrast exposure in patients undergoing coronary angiography (CAG) remains uncertai...

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Autores principales: Kuo, Chin-Sung, Chou, Ruey-Hsing, Lu, Ya-Wen, Tsai, Yi-Lin, Huang, Po-Hsun, Lin, Shing-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989666/
https://www.ncbi.nlm.nih.gov/pubmed/31996694
http://dx.doi.org/10.1038/s41598-020-58132-1
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author Kuo, Chin-Sung
Chou, Ruey-Hsing
Lu, Ya-Wen
Tsai, Yi-Lin
Huang, Po-Hsun
Lin, Shing-Jong
author_facet Kuo, Chin-Sung
Chou, Ruey-Hsing
Lu, Ya-Wen
Tsai, Yi-Lin
Huang, Po-Hsun
Lin, Shing-Jong
author_sort Kuo, Chin-Sung
collection PubMed
description Galectin-1 modulates acute and chronic inflammation, and is associated with glucose homeostasis and chronic renal disease. Whether the serum galectin-1 level can predict short-term and long-term renal outcomes after contrast exposure in patients undergoing coronary angiography (CAG) remains uncertain. This study aimed to evaluate the relationship between the serum galectin-1 level and the incidence of contrast-induced nephropathy (CIN), and to investigate the predictive role of the circulating galectin-1 level for renal function decline in patients undergoing CAG. In total, 798 patients who had undergone CAG were enrolled. Baseline creatinine and serum galectin-1 levels were determined before CAG. CIN was defined as an increase in the serum creatinine level of 0.5 mg/dl or a 25% increase from baseline within 48 h after the procedure, and renal function decline was defined as > 30% reduction of the estimated glomerular filtration rate from baseline. All patients were followed for at least 1 year or until the occurrence of death after CAG. Overall, CIN occurred in 41 (5.1%) patients. During a median follow-up period of 1.4 ± 1.1 years, 80 (10.0%) cases showed subsequent renal function decline. After adjustment for demographic characteristics, kidney function, traditional risk factors, and medications, higher galectin-1 levels were found to be associated independently with a greater risk of renal function decline [tertile 2: hazard ratio (HR) 5.56, 95% confidence interval (CI) 1.79–17.22; tertile 3: HR 5.56, 95% CI 1.97–16.32], but not with CIN, regardless of the presence of diabetes. In conclusion, higher baseline serum galectin-1 levels were associated with a greater risk of renal function decline in patients undergoing CAG, but were not associated independently with CIN.
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spelling pubmed-69896662020-02-05 Increased circulating galectin-1 levels are associated with the progression of kidney function decline in patients undergoing coronary angiography Kuo, Chin-Sung Chou, Ruey-Hsing Lu, Ya-Wen Tsai, Yi-Lin Huang, Po-Hsun Lin, Shing-Jong Sci Rep Article Galectin-1 modulates acute and chronic inflammation, and is associated with glucose homeostasis and chronic renal disease. Whether the serum galectin-1 level can predict short-term and long-term renal outcomes after contrast exposure in patients undergoing coronary angiography (CAG) remains uncertain. This study aimed to evaluate the relationship between the serum galectin-1 level and the incidence of contrast-induced nephropathy (CIN), and to investigate the predictive role of the circulating galectin-1 level for renal function decline in patients undergoing CAG. In total, 798 patients who had undergone CAG were enrolled. Baseline creatinine and serum galectin-1 levels were determined before CAG. CIN was defined as an increase in the serum creatinine level of 0.5 mg/dl or a 25% increase from baseline within 48 h after the procedure, and renal function decline was defined as > 30% reduction of the estimated glomerular filtration rate from baseline. All patients were followed for at least 1 year or until the occurrence of death after CAG. Overall, CIN occurred in 41 (5.1%) patients. During a median follow-up period of 1.4 ± 1.1 years, 80 (10.0%) cases showed subsequent renal function decline. After adjustment for demographic characteristics, kidney function, traditional risk factors, and medications, higher galectin-1 levels were found to be associated independently with a greater risk of renal function decline [tertile 2: hazard ratio (HR) 5.56, 95% confidence interval (CI) 1.79–17.22; tertile 3: HR 5.56, 95% CI 1.97–16.32], but not with CIN, regardless of the presence of diabetes. In conclusion, higher baseline serum galectin-1 levels were associated with a greater risk of renal function decline in patients undergoing CAG, but were not associated independently with CIN. Nature Publishing Group UK 2020-01-29 /pmc/articles/PMC6989666/ /pubmed/31996694 http://dx.doi.org/10.1038/s41598-020-58132-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kuo, Chin-Sung
Chou, Ruey-Hsing
Lu, Ya-Wen
Tsai, Yi-Lin
Huang, Po-Hsun
Lin, Shing-Jong
Increased circulating galectin-1 levels are associated with the progression of kidney function decline in patients undergoing coronary angiography
title Increased circulating galectin-1 levels are associated with the progression of kidney function decline in patients undergoing coronary angiography
title_full Increased circulating galectin-1 levels are associated with the progression of kidney function decline in patients undergoing coronary angiography
title_fullStr Increased circulating galectin-1 levels are associated with the progression of kidney function decline in patients undergoing coronary angiography
title_full_unstemmed Increased circulating galectin-1 levels are associated with the progression of kidney function decline in patients undergoing coronary angiography
title_short Increased circulating galectin-1 levels are associated with the progression of kidney function decline in patients undergoing coronary angiography
title_sort increased circulating galectin-1 levels are associated with the progression of kidney function decline in patients undergoing coronary angiography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989666/
https://www.ncbi.nlm.nih.gov/pubmed/31996694
http://dx.doi.org/10.1038/s41598-020-58132-1
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