Efficacy of Secukinumab for Plaque Psoriasis in a Patient on Hemodialysis

Secukinumab is effective to treat plaque psoriasis. However, the safety and efficiency of secukinumab have not been clarified in patients on hemodialysis. We report a 60-year-old Japanese woman. Plaque psoriasis was diagnosed at the age of 25 years and hemodialysis was started at the age of 39 years...

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Autores principales: Ikuma, Daiuske, Oguro, Masahiko, Hoshino, Junichi, Mizuno, Hiroki, Sekine, Akinari, Kawada, Masahiro, Hiramatsu, Rikako, Sumida, Keiichi, Hasegawa, Eiko, Hayami, Noriko, Yamanouchi, Masayuki, Suwabe, Tatsuya, Sawa, Naoki, Takaichi, Kenmei, Ubara, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990267/
https://www.ncbi.nlm.nih.gov/pubmed/31654299
http://dx.doi.org/10.1007/s13730-019-00426-z
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author Ikuma, Daiuske
Oguro, Masahiko
Hoshino, Junichi
Mizuno, Hiroki
Sekine, Akinari
Kawada, Masahiro
Hiramatsu, Rikako
Sumida, Keiichi
Hasegawa, Eiko
Hayami, Noriko
Yamanouchi, Masayuki
Suwabe, Tatsuya
Sawa, Naoki
Takaichi, Kenmei
Ubara, Yoshifumi
author_facet Ikuma, Daiuske
Oguro, Masahiko
Hoshino, Junichi
Mizuno, Hiroki
Sekine, Akinari
Kawada, Masahiro
Hiramatsu, Rikako
Sumida, Keiichi
Hasegawa, Eiko
Hayami, Noriko
Yamanouchi, Masayuki
Suwabe, Tatsuya
Sawa, Naoki
Takaichi, Kenmei
Ubara, Yoshifumi
author_sort Ikuma, Daiuske
collection PubMed
description Secukinumab is effective to treat plaque psoriasis. However, the safety and efficiency of secukinumab have not been clarified in patients on hemodialysis. We report a 60-year-old Japanese woman. Plaque psoriasis was diagnosed at the age of 25 years and hemodialysis was started at the age of 39 years. Her skin lesions persisted despite use of topical agents such as maxacalcitol and betamethasone. Accordingly, administration of secukinumab was started at a dose of 150 mg. The psoriasis area and severity index (PASI) score decreased from 49.8 to 14.8 after 2 weeks and to 0 after 6 weeks, with remission being maintained after 28 months. No adverse reactions were seen. This case indicates that secukinumab may be effective for severe psoriasis in patients on hemodialysis for end-stage renal disease.
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spelling pubmed-69902672020-02-14 Efficacy of Secukinumab for Plaque Psoriasis in a Patient on Hemodialysis Ikuma, Daiuske Oguro, Masahiko Hoshino, Junichi Mizuno, Hiroki Sekine, Akinari Kawada, Masahiro Hiramatsu, Rikako Sumida, Keiichi Hasegawa, Eiko Hayami, Noriko Yamanouchi, Masayuki Suwabe, Tatsuya Sawa, Naoki Takaichi, Kenmei Ubara, Yoshifumi CEN Case Rep Case Report Secukinumab is effective to treat plaque psoriasis. However, the safety and efficiency of secukinumab have not been clarified in patients on hemodialysis. We report a 60-year-old Japanese woman. Plaque psoriasis was diagnosed at the age of 25 years and hemodialysis was started at the age of 39 years. Her skin lesions persisted despite use of topical agents such as maxacalcitol and betamethasone. Accordingly, administration of secukinumab was started at a dose of 150 mg. The psoriasis area and severity index (PASI) score decreased from 49.8 to 14.8 after 2 weeks and to 0 after 6 weeks, with remission being maintained after 28 months. No adverse reactions were seen. This case indicates that secukinumab may be effective for severe psoriasis in patients on hemodialysis for end-stage renal disease. Springer Singapore 2019-10-25 /pmc/articles/PMC6990267/ /pubmed/31654299 http://dx.doi.org/10.1007/s13730-019-00426-z Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Ikuma, Daiuske
Oguro, Masahiko
Hoshino, Junichi
Mizuno, Hiroki
Sekine, Akinari
Kawada, Masahiro
Hiramatsu, Rikako
Sumida, Keiichi
Hasegawa, Eiko
Hayami, Noriko
Yamanouchi, Masayuki
Suwabe, Tatsuya
Sawa, Naoki
Takaichi, Kenmei
Ubara, Yoshifumi
Efficacy of Secukinumab for Plaque Psoriasis in a Patient on Hemodialysis
title Efficacy of Secukinumab for Plaque Psoriasis in a Patient on Hemodialysis
title_full Efficacy of Secukinumab for Plaque Psoriasis in a Patient on Hemodialysis
title_fullStr Efficacy of Secukinumab for Plaque Psoriasis in a Patient on Hemodialysis
title_full_unstemmed Efficacy of Secukinumab for Plaque Psoriasis in a Patient on Hemodialysis
title_short Efficacy of Secukinumab for Plaque Psoriasis in a Patient on Hemodialysis
title_sort efficacy of secukinumab for plaque psoriasis in a patient on hemodialysis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990267/
https://www.ncbi.nlm.nih.gov/pubmed/31654299
http://dx.doi.org/10.1007/s13730-019-00426-z
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