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Bacterial Metabolism and Antibiotic Efficacy

Antibiotics target energy-consuming processes. As such, perturbations to bacterial metabolic homeostasis are significant consequences of treatment. Here, we describe three postulates that collectively define antibiotic efficacy in the context of bacterial metabolism: (1) antibiotics alter the metabo...

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Detalles Bibliográficos
Autores principales: Stokes, Jonathan M., Lopatkin, Allison J., Lobritz, Michael A., Collins, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990394/
https://www.ncbi.nlm.nih.gov/pubmed/31279676
http://dx.doi.org/10.1016/j.cmet.2019.06.009
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author Stokes, Jonathan M.
Lopatkin, Allison J.
Lobritz, Michael A.
Collins, James J.
author_facet Stokes, Jonathan M.
Lopatkin, Allison J.
Lobritz, Michael A.
Collins, James J.
author_sort Stokes, Jonathan M.
collection PubMed
description Antibiotics target energy-consuming processes. As such, perturbations to bacterial metabolic homeostasis are significant consequences of treatment. Here, we describe three postulates that collectively define antibiotic efficacy in the context of bacterial metabolism: (1) antibiotics alter the metabolic state of bacteria, which contributes to the resulting death or stasis; (2) the metabolic state of bacteria influences their susceptibility to antibiotics; and (3) antibiotic efficacy can be enhanced by altering the metabolic state of bacteria. Altogether, we aim to emphasize the close relationship between bacterial metabolism and antibiotic efficacy as well as propose areas of exploration to develop novel antibiotics that optimally exploit bacterial metabolic networks.
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spelling pubmed-69903942020-02-03 Bacterial Metabolism and Antibiotic Efficacy Stokes, Jonathan M. Lopatkin, Allison J. Lobritz, Michael A. Collins, James J. Cell Metab Article Antibiotics target energy-consuming processes. As such, perturbations to bacterial metabolic homeostasis are significant consequences of treatment. Here, we describe three postulates that collectively define antibiotic efficacy in the context of bacterial metabolism: (1) antibiotics alter the metabolic state of bacteria, which contributes to the resulting death or stasis; (2) the metabolic state of bacteria influences their susceptibility to antibiotics; and (3) antibiotic efficacy can be enhanced by altering the metabolic state of bacteria. Altogether, we aim to emphasize the close relationship between bacterial metabolism and antibiotic efficacy as well as propose areas of exploration to develop novel antibiotics that optimally exploit bacterial metabolic networks. Cell Press 2019-08-06 /pmc/articles/PMC6990394/ /pubmed/31279676 http://dx.doi.org/10.1016/j.cmet.2019.06.009 Text en © 2020 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stokes, Jonathan M.
Lopatkin, Allison J.
Lobritz, Michael A.
Collins, James J.
Bacterial Metabolism and Antibiotic Efficacy
title Bacterial Metabolism and Antibiotic Efficacy
title_full Bacterial Metabolism and Antibiotic Efficacy
title_fullStr Bacterial Metabolism and Antibiotic Efficacy
title_full_unstemmed Bacterial Metabolism and Antibiotic Efficacy
title_short Bacterial Metabolism and Antibiotic Efficacy
title_sort bacterial metabolism and antibiotic efficacy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990394/
https://www.ncbi.nlm.nih.gov/pubmed/31279676
http://dx.doi.org/10.1016/j.cmet.2019.06.009
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