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Bacterial Metabolism and Antibiotic Efficacy
Antibiotics target energy-consuming processes. As such, perturbations to bacterial metabolic homeostasis are significant consequences of treatment. Here, we describe three postulates that collectively define antibiotic efficacy in the context of bacterial metabolism: (1) antibiotics alter the metabo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990394/ https://www.ncbi.nlm.nih.gov/pubmed/31279676 http://dx.doi.org/10.1016/j.cmet.2019.06.009 |
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author | Stokes, Jonathan M. Lopatkin, Allison J. Lobritz, Michael A. Collins, James J. |
author_facet | Stokes, Jonathan M. Lopatkin, Allison J. Lobritz, Michael A. Collins, James J. |
author_sort | Stokes, Jonathan M. |
collection | PubMed |
description | Antibiotics target energy-consuming processes. As such, perturbations to bacterial metabolic homeostasis are significant consequences of treatment. Here, we describe three postulates that collectively define antibiotic efficacy in the context of bacterial metabolism: (1) antibiotics alter the metabolic state of bacteria, which contributes to the resulting death or stasis; (2) the metabolic state of bacteria influences their susceptibility to antibiotics; and (3) antibiotic efficacy can be enhanced by altering the metabolic state of bacteria. Altogether, we aim to emphasize the close relationship between bacterial metabolism and antibiotic efficacy as well as propose areas of exploration to develop novel antibiotics that optimally exploit bacterial metabolic networks. |
format | Online Article Text |
id | pubmed-6990394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-69903942020-02-03 Bacterial Metabolism and Antibiotic Efficacy Stokes, Jonathan M. Lopatkin, Allison J. Lobritz, Michael A. Collins, James J. Cell Metab Article Antibiotics target energy-consuming processes. As such, perturbations to bacterial metabolic homeostasis are significant consequences of treatment. Here, we describe three postulates that collectively define antibiotic efficacy in the context of bacterial metabolism: (1) antibiotics alter the metabolic state of bacteria, which contributes to the resulting death or stasis; (2) the metabolic state of bacteria influences their susceptibility to antibiotics; and (3) antibiotic efficacy can be enhanced by altering the metabolic state of bacteria. Altogether, we aim to emphasize the close relationship between bacterial metabolism and antibiotic efficacy as well as propose areas of exploration to develop novel antibiotics that optimally exploit bacterial metabolic networks. Cell Press 2019-08-06 /pmc/articles/PMC6990394/ /pubmed/31279676 http://dx.doi.org/10.1016/j.cmet.2019.06.009 Text en © 2020 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Stokes, Jonathan M. Lopatkin, Allison J. Lobritz, Michael A. Collins, James J. Bacterial Metabolism and Antibiotic Efficacy |
title | Bacterial Metabolism and Antibiotic Efficacy |
title_full | Bacterial Metabolism and Antibiotic Efficacy |
title_fullStr | Bacterial Metabolism and Antibiotic Efficacy |
title_full_unstemmed | Bacterial Metabolism and Antibiotic Efficacy |
title_short | Bacterial Metabolism and Antibiotic Efficacy |
title_sort | bacterial metabolism and antibiotic efficacy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990394/ https://www.ncbi.nlm.nih.gov/pubmed/31279676 http://dx.doi.org/10.1016/j.cmet.2019.06.009 |
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