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Kinetics of maternally-derived serogroup A, C, Y and W-specific meningococcal immunoglobulin G in Malian women and infants

A prospective, randomised, controlled observer-blind trial measuring the efficacy and immunogenicity of trivalent influenza vaccine (TIV) and the immunogenicity of quadrivalent meningococcal conjugate vaccine (MCV) in pregnant women and their infants up to 6 months of age was conducted in Mali. Here...

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Autores principales: Findlow, H., Tapia, M.D., Sow, S.O., Haidara, F.C., Coulibaly, F., Keita, A.M., Diallo, F., Doumbia, M., Traore, A., Schluterman, N., Clark, D.A., Borrow, R., Levine, M.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990398/
https://www.ncbi.nlm.nih.gov/pubmed/30952500
http://dx.doi.org/10.1016/j.vaccine.2019.03.045
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author Findlow, H.
Tapia, M.D.
Sow, S.O.
Haidara, F.C.
Coulibaly, F.
Keita, A.M.
Diallo, F.
Doumbia, M.
Traore, A.
Schluterman, N.
Clark, D.A.
Borrow, R.
Levine, M.M.
author_facet Findlow, H.
Tapia, M.D.
Sow, S.O.
Haidara, F.C.
Coulibaly, F.
Keita, A.M.
Diallo, F.
Doumbia, M.
Traore, A.
Schluterman, N.
Clark, D.A.
Borrow, R.
Levine, M.M.
author_sort Findlow, H.
collection PubMed
description A prospective, randomised, controlled observer-blind trial measuring the efficacy and immunogenicity of trivalent influenza vaccine (TIV) and the immunogenicity of quadrivalent meningococcal conjugate vaccine (MCV) in pregnant women and their infants up to 6 months of age was conducted in Mali. Here we reported the immunogenicity of MCV, which was used as a comparator vaccine to TIV, in this population. Third-trimester pregnant Malian women were randomized to receive TIV or MCV. Blood samples were collected from women prior to vaccination, 28 days post-vaccination, at delivery and 3 and 6 months post-delivery and from infants at birth and 3 and 6 months of age. Meningococcal-specific serogroup (Men) A, C, Y and W-specific antibodies were measured by enzyme linked immunosorbent assay in a randomly selected subset of 50 mother-infant pairs where the mother had received MCV. At birth, 94.0% (47/50) of infants had MenA specific IgG levels ≥ 2 µg/mL decreasing to 72.9% and 30.4% at 3 and 6 months of age. For MenC, 81.3% (39/48) of infants had MenC specific IgG levels ≥ 2 µg/mL at birth decreasing to 29.4% and 17.8% at 3 and 6 months of age. For MenY, 89.6% (43/48) of infants had MenY specific IgG levels ≥ 2 µg/mL at birth decreasing to 64.6% and 62.5% at 3 and 6 months of age. For MenW, 89.6% (43/48) of infants had MenW specific IgG levels ≥ 2 μg/ml at birth decreasing to 62.5% and 41.7% at 3 and 6 months of age. Maternal immunization with MCV conveyed protective levels of IgG at birth through to 3 months of age in the majority of infants.
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spelling pubmed-69903982020-02-05 Kinetics of maternally-derived serogroup A, C, Y and W-specific meningococcal immunoglobulin G in Malian women and infants Findlow, H. Tapia, M.D. Sow, S.O. Haidara, F.C. Coulibaly, F. Keita, A.M. Diallo, F. Doumbia, M. Traore, A. Schluterman, N. Clark, D.A. Borrow, R. Levine, M.M. Vaccine Article A prospective, randomised, controlled observer-blind trial measuring the efficacy and immunogenicity of trivalent influenza vaccine (TIV) and the immunogenicity of quadrivalent meningococcal conjugate vaccine (MCV) in pregnant women and their infants up to 6 months of age was conducted in Mali. Here we reported the immunogenicity of MCV, which was used as a comparator vaccine to TIV, in this population. Third-trimester pregnant Malian women were randomized to receive TIV or MCV. Blood samples were collected from women prior to vaccination, 28 days post-vaccination, at delivery and 3 and 6 months post-delivery and from infants at birth and 3 and 6 months of age. Meningococcal-specific serogroup (Men) A, C, Y and W-specific antibodies were measured by enzyme linked immunosorbent assay in a randomly selected subset of 50 mother-infant pairs where the mother had received MCV. At birth, 94.0% (47/50) of infants had MenA specific IgG levels ≥ 2 µg/mL decreasing to 72.9% and 30.4% at 3 and 6 months of age. For MenC, 81.3% (39/48) of infants had MenC specific IgG levels ≥ 2 µg/mL at birth decreasing to 29.4% and 17.8% at 3 and 6 months of age. For MenY, 89.6% (43/48) of infants had MenY specific IgG levels ≥ 2 µg/mL at birth decreasing to 64.6% and 62.5% at 3 and 6 months of age. For MenW, 89.6% (43/48) of infants had MenW specific IgG levels ≥ 2 μg/ml at birth decreasing to 62.5% and 41.7% at 3 and 6 months of age. Maternal immunization with MCV conveyed protective levels of IgG at birth through to 3 months of age in the majority of infants. Elsevier Science 2019-04-24 /pmc/articles/PMC6990398/ /pubmed/30952500 http://dx.doi.org/10.1016/j.vaccine.2019.03.045 Text en © 2020 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Findlow, H.
Tapia, M.D.
Sow, S.O.
Haidara, F.C.
Coulibaly, F.
Keita, A.M.
Diallo, F.
Doumbia, M.
Traore, A.
Schluterman, N.
Clark, D.A.
Borrow, R.
Levine, M.M.
Kinetics of maternally-derived serogroup A, C, Y and W-specific meningococcal immunoglobulin G in Malian women and infants
title Kinetics of maternally-derived serogroup A, C, Y and W-specific meningococcal immunoglobulin G in Malian women and infants
title_full Kinetics of maternally-derived serogroup A, C, Y and W-specific meningococcal immunoglobulin G in Malian women and infants
title_fullStr Kinetics of maternally-derived serogroup A, C, Y and W-specific meningococcal immunoglobulin G in Malian women and infants
title_full_unstemmed Kinetics of maternally-derived serogroup A, C, Y and W-specific meningococcal immunoglobulin G in Malian women and infants
title_short Kinetics of maternally-derived serogroup A, C, Y and W-specific meningococcal immunoglobulin G in Malian women and infants
title_sort kinetics of maternally-derived serogroup a, c, y and w-specific meningococcal immunoglobulin g in malian women and infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990398/
https://www.ncbi.nlm.nih.gov/pubmed/30952500
http://dx.doi.org/10.1016/j.vaccine.2019.03.045
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