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Impact of Maleimide Disubstitution on Chemical and Biological Characteristics of HER2 Antibody–Drug Conjugates

[Image: see text] Antibody–drug conjugates (ADCs) are the spearhead of targeted therapies. According to the technology used, the conjugation of a cytotoxic drug to an antibody can produce suboptimal heterogeneous species, impacting the overall efficacy. Herein, we describe the synthesis of HER2-targ...

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Detalles Bibliográficos
Autores principales:	Feuillâtre, Ofelia, Gély, Camille, Huvelle, Steve, Baltus, Christine B., Juen, Ludovic, Joubert, Nicolas, Desgranges, Audrey, Viaud-Massuard, Marie-Claude, Martin, Camille
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990629/ https://www.ncbi.nlm.nih.gov/pubmed/32010829 http://dx.doi.org/10.1021/acsomega.9b03510

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