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Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents

[Image: see text] Glipizide (GLZ) is an oral hypoglycemic agent, which is a weakly aqueous soluble drug. The solubility values of GLZ in various neat solvents are scarce in the literature. Hence, the solubility of GLZ in 12 different neat solvents, namely, “water, methanol, ethanol, isopropanol (IPA...

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Autores principales: Kalam, Mohd Abul, Alshamsan, Aws, Alkholief, Musaed, Alsarra, Ibrahim A., Ali, Raisuddin, Haq, Nazrul, Anwer, Md Khalid, Shakeel, Faiyaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990636/
https://www.ncbi.nlm.nih.gov/pubmed/32010845
http://dx.doi.org/10.1021/acsomega.9b04004
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author Kalam, Mohd Abul
Alshamsan, Aws
Alkholief, Musaed
Alsarra, Ibrahim A.
Ali, Raisuddin
Haq, Nazrul
Anwer, Md Khalid
Shakeel, Faiyaz
author_facet Kalam, Mohd Abul
Alshamsan, Aws
Alkholief, Musaed
Alsarra, Ibrahim A.
Ali, Raisuddin
Haq, Nazrul
Anwer, Md Khalid
Shakeel, Faiyaz
author_sort Kalam, Mohd Abul
collection PubMed
description [Image: see text] Glipizide (GLZ) is an oral hypoglycemic agent, which is a weakly aqueous soluble drug. The solubility values of GLZ in various neat solvents are scarce in the literature. Hence, the solubility of GLZ in 12 different neat solvents, namely, “water, methanol, ethanol, isopropanol (IPA), 1-butanol, 2-butanol, ethylene glycol (EG), propylene glycol (PG), poly(ethylene glycol)-400 (PEG-400), ethyl acetate (EA), dimethyl sulfoxide (DMSO), and Transcutol-HP (THP)”, at “T = 298.2–318.2 K” and “p = 0.1 MPa” was measured. The recorded solubilities of GLZ were correlated by “van’t Hoff and Apelblat models” using root-mean-square deviation (RMSD). The overall RMSD was obtained as 1.21 and 1.40% for “Apelblat and van’t Hoff models”, respectively. Different solubility parameters of all studied materials including drug and solvent were calculated to find the best solvent for GLZ. The solubilities of GLZ (expressed in mole fraction) have been found highest in DMSO (2.81 × 10(–2)), followed by THP, EA, 2-butanol, 1-butanol, IPA, PEG-400, ethanol, PG, methanol, EG, and water (1.98 × 10(–4)) at “T = 318.2 K”. All investigated solubility parameters of GLZ were recorded very close to the DMSO. “Apparent thermodynamic analysis” showed an “endothermic and entropy-driven dissolution” of GLZ in the 12 different neat solvents. The highest molecular interactions were recorded in GLZ–DMSO compared to other combinations. Overall, DMSO has been considered as the best solvent for the solubilization of GLZ.
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spelling pubmed-69906362020-01-31 Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents Kalam, Mohd Abul Alshamsan, Aws Alkholief, Musaed Alsarra, Ibrahim A. Ali, Raisuddin Haq, Nazrul Anwer, Md Khalid Shakeel, Faiyaz ACS Omega [Image: see text] Glipizide (GLZ) is an oral hypoglycemic agent, which is a weakly aqueous soluble drug. The solubility values of GLZ in various neat solvents are scarce in the literature. Hence, the solubility of GLZ in 12 different neat solvents, namely, “water, methanol, ethanol, isopropanol (IPA), 1-butanol, 2-butanol, ethylene glycol (EG), propylene glycol (PG), poly(ethylene glycol)-400 (PEG-400), ethyl acetate (EA), dimethyl sulfoxide (DMSO), and Transcutol-HP (THP)”, at “T = 298.2–318.2 K” and “p = 0.1 MPa” was measured. The recorded solubilities of GLZ were correlated by “van’t Hoff and Apelblat models” using root-mean-square deviation (RMSD). The overall RMSD was obtained as 1.21 and 1.40% for “Apelblat and van’t Hoff models”, respectively. Different solubility parameters of all studied materials including drug and solvent were calculated to find the best solvent for GLZ. The solubilities of GLZ (expressed in mole fraction) have been found highest in DMSO (2.81 × 10(–2)), followed by THP, EA, 2-butanol, 1-butanol, IPA, PEG-400, ethanol, PG, methanol, EG, and water (1.98 × 10(–4)) at “T = 318.2 K”. All investigated solubility parameters of GLZ were recorded very close to the DMSO. “Apparent thermodynamic analysis” showed an “endothermic and entropy-driven dissolution” of GLZ in the 12 different neat solvents. The highest molecular interactions were recorded in GLZ–DMSO compared to other combinations. Overall, DMSO has been considered as the best solvent for the solubilization of GLZ. American Chemical Society 2020-01-10 /pmc/articles/PMC6990636/ /pubmed/32010845 http://dx.doi.org/10.1021/acsomega.9b04004 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Kalam, Mohd Abul
Alshamsan, Aws
Alkholief, Musaed
Alsarra, Ibrahim A.
Ali, Raisuddin
Haq, Nazrul
Anwer, Md Khalid
Shakeel, Faiyaz
Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents
title Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents
title_full Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents
title_fullStr Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents
title_full_unstemmed Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents
title_short Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents
title_sort solubility measurement and various solubility parameters of glipizide in different neat solvents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990636/
https://www.ncbi.nlm.nih.gov/pubmed/32010845
http://dx.doi.org/10.1021/acsomega.9b04004
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