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Electroencephalography studies of hypoxic ischemia in fetal and neonatal animal models
Alongside clinical achievements, experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ischemic encephalopathy (HIE). Due to the reasonably fair degree of flexibility with experime...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990791/ https://www.ncbi.nlm.nih.gov/pubmed/31719243 http://dx.doi.org/10.4103/1673-5374.268892 |
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author | Abbasi, Hamid Unsworth, Charles P. |
author_facet | Abbasi, Hamid Unsworth, Charles P. |
author_sort | Abbasi, Hamid |
collection | PubMed |
description | Alongside clinical achievements, experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ischemic encephalopathy (HIE). Due to the reasonably fair degree of flexibility with experiments, most of the research around HIE in the literature has been largely concerned with the neurodevelopmental outcome or how the frequency and duration of HI seizures could relate to the severity of perinatal brain injury, following HI insult. This survey concentrates on how EEG experimental studies using asphyxiated animal models (in rodents, piglets, sheep and non-human primate monkeys) provide a unique opportunity to examine from the exact time of HI event to help gain insights into HIE where human studies become difficult. |
format | Online Article Text |
id | pubmed-6990791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-69907912020-02-10 Electroencephalography studies of hypoxic ischemia in fetal and neonatal animal models Abbasi, Hamid Unsworth, Charles P. Neural Regen Res Review Alongside clinical achievements, experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ischemic encephalopathy (HIE). Due to the reasonably fair degree of flexibility with experiments, most of the research around HIE in the literature has been largely concerned with the neurodevelopmental outcome or how the frequency and duration of HI seizures could relate to the severity of perinatal brain injury, following HI insult. This survey concentrates on how EEG experimental studies using asphyxiated animal models (in rodents, piglets, sheep and non-human primate monkeys) provide a unique opportunity to examine from the exact time of HI event to help gain insights into HIE where human studies become difficult. Wolters Kluwer - Medknow 2019-11-08 /pmc/articles/PMC6990791/ /pubmed/31719243 http://dx.doi.org/10.4103/1673-5374.268892 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Abbasi, Hamid Unsworth, Charles P. Electroencephalography studies of hypoxic ischemia in fetal and neonatal animal models |
title | Electroencephalography studies of hypoxic ischemia in fetal and neonatal animal models |
title_full | Electroencephalography studies of hypoxic ischemia in fetal and neonatal animal models |
title_fullStr | Electroencephalography studies of hypoxic ischemia in fetal and neonatal animal models |
title_full_unstemmed | Electroencephalography studies of hypoxic ischemia in fetal and neonatal animal models |
title_short | Electroencephalography studies of hypoxic ischemia in fetal and neonatal animal models |
title_sort | electroencephalography studies of hypoxic ischemia in fetal and neonatal animal models |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990791/ https://www.ncbi.nlm.nih.gov/pubmed/31719243 http://dx.doi.org/10.4103/1673-5374.268892 |
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