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NVP-BEZ235 inhibits thyroid cancer growth by p53- dependent/independent p21 upregulation

NVP-BEZ235 is a novel dual PI3K/mTOR inhibitor, currently in phase 1/2 clinical trials, exhibiting clinical efficiency in treatment of numerous malignancies including thyroid cancer. Cancer cells harboring mutant p53 was widely reported to be blunt to pharmaceutical therapies. However, whether this...

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Detalles Bibliográficos
Autores principales:	Ruan, Banjun, Liu, Wei, Chen, Pu, Cui, Rongrong, Li, Yu, Ji, Meiju, Hou, Peng, Yang, Qi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990918/ https://www.ncbi.nlm.nih.gov/pubmed/32025215 http://dx.doi.org/10.7150/ijbs.37592

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