Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine‐gingipain inhibitor COR388

COR388, a small‐molecule lysine‐gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease. Gingipains are produced by two species of bacteria, Porphyromonas gingivalis and Porphyromonas gulae...

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Detalles Bibliográficos
Autores principales: Arastu‐Kapur, Shirin, Nguyen, Mai, Raha, Debasish, Ermini, Florian, Haditsch, Ursula, Araujo, Joseph, De Lannoy, Ines A. M., Ryder, Mark I., Dominy, Stephen S., Lynch, Casey, Holsinger, Leslie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990966/
https://www.ncbi.nlm.nih.gov/pubmed/31999052
http://dx.doi.org/10.1002/prp2.562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990966/
https://www.ncbi.nlm.nih.gov/pubmed/31999052
http://dx.doi.org/10.1002/prp2.562

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