m(6)A facilitates YTHDF‐independent phase separation

N6‐methyladenosine (m(6)A) is one of the most abundant messenger RNA (mRNA) modifications in eukaryotes and is involved in various key processes of RNA metabolism. In this issue of Nature, Ries et al (2019) described the fundamental features of m6A modification of mRNAs in regulating the composition...

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Detalles Bibliográficos
Autores principales: Liu, Si‐Yu, Feng, Yi, Wu, Jun-Jie, Zou, Ming-Li, Sun, Zi-Li, Li, Xia, Yuan, Feng‐Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991661/
https://www.ncbi.nlm.nih.gov/pubmed/31802598
http://dx.doi.org/10.1111/jcmm.14847
Descripción
Sumario:N6‐methyladenosine (m(6)A) is one of the most abundant messenger RNA (mRNA) modifications in eukaryotes and is involved in various key processes of RNA metabolism. In this issue of Nature, Ries et al (2019) described the fundamental features of m6A modification of mRNAs in regulating the composition of the phase‐separated transcriptome on the basis of number and distribution, and provide strong evidence that m6A plays a role in regulating phase separation in cells.

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