Cargando…

Metabolic imaging using hyperpolarized (13)C‐pyruvate to assess sensitivity to the B‐Raf inhibitor vemurafenib in melanoma cells and xenografts

Nearly all melanoma patients with a BRAF‐activating mutation will develop resistance after an initial clinical benefit from BRAF inhibition (BRAFi). The aim of this work is to evaluate whether metabolic imaging using hyperpolarized (HP) (13)C pyruvate can serve as a metabolic marker of early respons...

Descripción completa

Detalles Bibliográficos
Autores principales:	Acciardo, Stefania, Mignion, Lionel, Lacomblez, Estelle, Schoonjans, Céline, Joudiou, Nicolas, Gourgue, Florian, Bouzin, Caroline, Baurain, Jean‐François, Gallez, Bernard, Jordan, Bénédicte F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991684/ https://www.ncbi.nlm.nih.gov/pubmed/31833658 http://dx.doi.org/10.1111/jcmm.14890

Ejemplares similares

Imaging markers of response to combined BRAF and MEK inhibition in BRAF mutated vemurafenib-sensitive and resistant melanomas
por: Acciardo, Stefania, et al.
Publicado: (2018)

Hyperpolarized (13)C-Pyruvate to Assess Response to Anti-PD1 Immune Checkpoint Inhibition in YUMMER 1.7 Melanoma Xenografts
por: Farah, Chantale, et al.
Publicado: (2023)

Combined HP (13)C Pyruvate and (13)C-Glucose Fluxomic as a Potential Marker of Response to Targeted Therapies in YUMM1.7 Melanoma Xenografts
por: Farah, Chantale, et al.
Publicado: (2022)

Obesity and triple‐negative‐breast‐cancer: Is apelin a new key target?
por: Gourgue, Florian, et al.
Publicado: (2020)

Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI
por: Buyse, Chloé, et al.
Publicado: (2021)

Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1
por: Schoonjans, Céline A., et al.
Publicado: (2020)

Acetate: Friend or foe against breast tumour growth in the context of obesity?
por: Yelek, Caner, et al.
Publicado: (2020)

Evaluation of Syrosingopine, an MCT Inhibitor, as Potential Modulator of Tumor Metabolism and Extracellular Acidification
por: Buyse, Chloe, et al.
Publicado: (2022)

Statins Alleviate Tumor Hypoxia in Prostate Cancer Models by Decreasing Oxygen Consumption: An Opportunity for Radiosensitization?
por: d’Hose, Donatienne, et al.
Publicado: (2022)

Contribution of macrophages in the contrast loss in iron oxide-based MRI cancer cell tracking studies
por: Danhier, Pierre, et al.
Publicado: (2017)

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
por: Corbet, Cyril, et al.
Publicado: (2018)

Synthesis of (13)C and (2)H Labeled Vinyl Pyruvate and Hyperpolarization of Pyruvate
por: Brahms, Arne, et al.
Publicado: (2022)

EPR Investigations to Study the Impact of Mito-Metformin on the Mitochondrial Function of Prostate Cancer Cells
por: d’Hose, Donatienne, et al.
Publicado: (2022)

Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer
por: Yelek, Caner, et al.
Publicado: (2022)

Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse
por: Marco-Rius, Irene, et al.
Publicado: (2013)

Probing Early Tumor Response to Radiation Therapy Using Hyperpolarized [1-(13)C]pyruvate in MDA-MB-231 Xenografts
por: Chen, Albert P., et al.
Publicado: (2013)

B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells
por: Roos, Wynand P., et al.
Publicado: (2014)

Correction: Probing Early Tumor Response to Radiation Therapy Using Hyperpolarized [1-(13)C]pyruvate in MDA-MB-231 Xenografts
por: Chen, Albert P., et al.
Publicado: (2013)

Pyruvate‐lactate exchange and glucose uptake in human prostate cancer cell models. A study in xenografts and suspensions by hyperpolarized [1‐(13)C]pyruvate MRS and [(18)F]FDG‐PET
por: van Heijster, Frits H.A., et al.
Publicado: (2020)

Radical‐free hyperpolarized MRI using endogenously occurring pyruvate analogues and UV‐induced nonpersistent radicals
por: Zanella, Claudia C., et al.
Publicado: (2021)

Discovery of a PFKFB3 inhibitor for phase I trial testing that synergizes with the B-Raf inhibitor vemurafenib
por: Telang, Sucheta, et al.
Publicado: (2014)

A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C‐pyruvate
por: Daniels, Charlie J., et al.
Publicado: (2016)

Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate
por: Serrao, Eva M., et al.
Publicado: (2016)

Molecular detection of inflammation in cell models using hyperpolarized (13)C-pyruvate
por: Sriram, Renuka, et al.
Publicado: (2018)

Current Methods for Hyperpolarized [1-13C]pyruvate MRI Human Studies
por: Larson, Peder EZ, et al.
Publicado: (2023)

Combined endogenous MR biomarkers to assess changes in tumor oxygenation induced by an allosteric effector of hemoglobin
por: Cao‐Pham, Thanh‐Trang, et al.
Publicado: (2019)

Optimising the combination dosing strategy of abemaciclib and vemurafenib in BRAF-mutated melanoma xenograft tumours
por: Tate, Sonya C, et al.
Publicado: (2016)

Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts
por: Kemper, Kristel, et al.
Publicado: (2015)

Oxygen Mapping within Healthy and Acutely Infarcted Brain Tissue in Humans Using the NMR Relaxation of Lipids: A Proof-Of-Concept Translational Study
por: Colliez, Florence, et al.
Publicado: (2015)

A Catalyzing Phantom for Reproducible Dynamic Conversion of Hyperpolarized [1-(13)C]-Pyruvate
por: Walker, Christopher M., et al.
Publicado: (2013)

Metabolism of hyperpolarized [1‐(13)C]pyruvate through alternate pathways in rat liver
por: Jin, Eunsook S., et al.
Publicado: (2016)

Effects of fasting on serial measurements of hyperpolarized [1‐(13)C]pyruvate metabolism in tumors
por: Serrao, Eva M., et al.
Publicado: (2016)

Hyperpolarized [1‐(13)C] pyruvate as a possible diagnostic tool in liver disease
por: Kjærgaard, Uffe, et al.
Publicado: (2018)

Imaging Hyperpolarized Pyruvate and Lactate after Blood–Brain Barrier Disruption with Focused Ultrasound
por: Peeters, Tom H., et al.
Publicado: (2019)

Detecting de novo Hepatic Ketogenesis Using Hyperpolarized [2-(13)C] Pyruvate
por: Ragavan, Mukundan, et al.
Publicado: (2022)

Lactate saturation limits bicarbonate detection in hyperpolarized (13)C‐pyruvate MRI of the brain
por: Bøgh, Nikolaj, et al.
Publicado: (2022)

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
por: Ladds, Marcus J. G. W., et al.
Publicado: (2018)

Adipose Tissue Metabolism and Cancer Progression: Novel Insights from Gut Microbiota?
por: Jordan, Benedicte F., et al.
Publicado: (2017)

Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized (13)C Pyruvate MRI
por: Sriram, Renuka, et al.
Publicado: (2018)

Detection of 3D Cardiac metabolism after injection of hyperpolarized [1-13C]pyruvate
por: Frijia, Francesca, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_a7lem2jl5jp3vk7aaomn2vjb86