Cargando…
Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents
Oligonucleotide drugs represent an emerging area in the pharmaceutical industry. Solid-phase synthesis generates many structurally closely related impurities, making efficient separation systems for purification and analysis a key challenge during pharmaceutical drug development. To increase the fun...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992550/ https://www.ncbi.nlm.nih.gov/pubmed/31814048 http://dx.doi.org/10.1007/s00216-019-02236-9 |