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Manipulation of the Innate Immune Response by Varicella Zoster Virus

Varicella zoster virus (VZV) is the causative agent of chickenpox (varicella) and shingles (herpes zoster). VZV and other members of the herpesvirus family are distinguished by their ability to establish a latent infection, with the potential to reactivate and spread virus to other susceptible indiv...

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Autores principales: Gerada, Chelsea, Campbell, Tessa M., Kennedy, Jarrod J., McSharry, Brian P., Steain, Megan, Slobedman, Barry, Abendroth, Allison
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992605/
https://www.ncbi.nlm.nih.gov/pubmed/32038653
http://dx.doi.org/10.3389/fimmu.2020.00001
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author Gerada, Chelsea
Campbell, Tessa M.
Kennedy, Jarrod J.
McSharry, Brian P.
Steain, Megan
Slobedman, Barry
Abendroth, Allison
author_facet Gerada, Chelsea
Campbell, Tessa M.
Kennedy, Jarrod J.
McSharry, Brian P.
Steain, Megan
Slobedman, Barry
Abendroth, Allison
author_sort Gerada, Chelsea
collection PubMed
description Varicella zoster virus (VZV) is the causative agent of chickenpox (varicella) and shingles (herpes zoster). VZV and other members of the herpesvirus family are distinguished by their ability to establish a latent infection, with the potential to reactivate and spread virus to other susceptible individuals. This lifelong relationship continually subjects VZV to the host immune system and as such VZV has evolved a plethora of strategies to evade and manipulate the immune response. This review will focus on our current understanding of the innate anti-viral control mechanisms faced by VZV. We will also discuss the diverse array of strategies employed by VZV to regulate these innate immune responses and highlight new knowledge on the interactions between VZV and human innate immune cells.
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spelling pubmed-69926052020-02-07 Manipulation of the Innate Immune Response by Varicella Zoster Virus Gerada, Chelsea Campbell, Tessa M. Kennedy, Jarrod J. McSharry, Brian P. Steain, Megan Slobedman, Barry Abendroth, Allison Front Immunol Immunology Varicella zoster virus (VZV) is the causative agent of chickenpox (varicella) and shingles (herpes zoster). VZV and other members of the herpesvirus family are distinguished by their ability to establish a latent infection, with the potential to reactivate and spread virus to other susceptible individuals. This lifelong relationship continually subjects VZV to the host immune system and as such VZV has evolved a plethora of strategies to evade and manipulate the immune response. This review will focus on our current understanding of the innate anti-viral control mechanisms faced by VZV. We will also discuss the diverse array of strategies employed by VZV to regulate these innate immune responses and highlight new knowledge on the interactions between VZV and human innate immune cells. Frontiers Media S.A. 2020-01-24 /pmc/articles/PMC6992605/ /pubmed/32038653 http://dx.doi.org/10.3389/fimmu.2020.00001 Text en Copyright © 2020 Gerada, Campbell, Kennedy, McSharry, Steain, Slobedman and Abendroth. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Gerada, Chelsea
Campbell, Tessa M.
Kennedy, Jarrod J.
McSharry, Brian P.
Steain, Megan
Slobedman, Barry
Abendroth, Allison
Manipulation of the Innate Immune Response by Varicella Zoster Virus
title Manipulation of the Innate Immune Response by Varicella Zoster Virus
title_full Manipulation of the Innate Immune Response by Varicella Zoster Virus
title_fullStr Manipulation of the Innate Immune Response by Varicella Zoster Virus
title_full_unstemmed Manipulation of the Innate Immune Response by Varicella Zoster Virus
title_short Manipulation of the Innate Immune Response by Varicella Zoster Virus
title_sort manipulation of the innate immune response by varicella zoster virus
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992605/
https://www.ncbi.nlm.nih.gov/pubmed/32038653
http://dx.doi.org/10.3389/fimmu.2020.00001
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