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Manipulation of the Innate Immune Response by Varicella Zoster Virus
Varicella zoster virus (VZV) is the causative agent of chickenpox (varicella) and shingles (herpes zoster). VZV and other members of the herpesvirus family are distinguished by their ability to establish a latent infection, with the potential to reactivate and spread virus to other susceptible indiv...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992605/ https://www.ncbi.nlm.nih.gov/pubmed/32038653 http://dx.doi.org/10.3389/fimmu.2020.00001 |
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author | Gerada, Chelsea Campbell, Tessa M. Kennedy, Jarrod J. McSharry, Brian P. Steain, Megan Slobedman, Barry Abendroth, Allison |
author_facet | Gerada, Chelsea Campbell, Tessa M. Kennedy, Jarrod J. McSharry, Brian P. Steain, Megan Slobedman, Barry Abendroth, Allison |
author_sort | Gerada, Chelsea |
collection | PubMed |
description | Varicella zoster virus (VZV) is the causative agent of chickenpox (varicella) and shingles (herpes zoster). VZV and other members of the herpesvirus family are distinguished by their ability to establish a latent infection, with the potential to reactivate and spread virus to other susceptible individuals. This lifelong relationship continually subjects VZV to the host immune system and as such VZV has evolved a plethora of strategies to evade and manipulate the immune response. This review will focus on our current understanding of the innate anti-viral control mechanisms faced by VZV. We will also discuss the diverse array of strategies employed by VZV to regulate these innate immune responses and highlight new knowledge on the interactions between VZV and human innate immune cells. |
format | Online Article Text |
id | pubmed-6992605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69926052020-02-07 Manipulation of the Innate Immune Response by Varicella Zoster Virus Gerada, Chelsea Campbell, Tessa M. Kennedy, Jarrod J. McSharry, Brian P. Steain, Megan Slobedman, Barry Abendroth, Allison Front Immunol Immunology Varicella zoster virus (VZV) is the causative agent of chickenpox (varicella) and shingles (herpes zoster). VZV and other members of the herpesvirus family are distinguished by their ability to establish a latent infection, with the potential to reactivate and spread virus to other susceptible individuals. This lifelong relationship continually subjects VZV to the host immune system and as such VZV has evolved a plethora of strategies to evade and manipulate the immune response. This review will focus on our current understanding of the innate anti-viral control mechanisms faced by VZV. We will also discuss the diverse array of strategies employed by VZV to regulate these innate immune responses and highlight new knowledge on the interactions between VZV and human innate immune cells. Frontiers Media S.A. 2020-01-24 /pmc/articles/PMC6992605/ /pubmed/32038653 http://dx.doi.org/10.3389/fimmu.2020.00001 Text en Copyright © 2020 Gerada, Campbell, Kennedy, McSharry, Steain, Slobedman and Abendroth. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Gerada, Chelsea Campbell, Tessa M. Kennedy, Jarrod J. McSharry, Brian P. Steain, Megan Slobedman, Barry Abendroth, Allison Manipulation of the Innate Immune Response by Varicella Zoster Virus |
title | Manipulation of the Innate Immune Response by Varicella Zoster Virus |
title_full | Manipulation of the Innate Immune Response by Varicella Zoster Virus |
title_fullStr | Manipulation of the Innate Immune Response by Varicella Zoster Virus |
title_full_unstemmed | Manipulation of the Innate Immune Response by Varicella Zoster Virus |
title_short | Manipulation of the Innate Immune Response by Varicella Zoster Virus |
title_sort | manipulation of the innate immune response by varicella zoster virus |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992605/ https://www.ncbi.nlm.nih.gov/pubmed/32038653 http://dx.doi.org/10.3389/fimmu.2020.00001 |
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