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Afterdischarges of Spinal Interneurons Following a Brief High-Frequency Stimulation of Ia Afferents in the Cat

Spinal motoneurons exhibit sustained afterdischarges and plateau potentials following a brief high-frequency stimulation of Ia afferents. Also, there is evidence that spinal cord interneurons exhibit plateau potentials. However, to our knowledge, there are no reports about the possible afterdischarg...

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Autores principales: Méndez-Fernández, Abraham, Moreno-Castillo, Mayra, Huidobro, Nayeli, Flores, Amira, Manjarrez, Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992651/
https://www.ncbi.nlm.nih.gov/pubmed/32038185
http://dx.doi.org/10.3389/fnint.2019.00075
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author Méndez-Fernández, Abraham
Moreno-Castillo, Mayra
Huidobro, Nayeli
Flores, Amira
Manjarrez, Elias
author_facet Méndez-Fernández, Abraham
Moreno-Castillo, Mayra
Huidobro, Nayeli
Flores, Amira
Manjarrez, Elias
author_sort Méndez-Fernández, Abraham
collection PubMed
description Spinal motoneurons exhibit sustained afterdischarges and plateau potentials following a brief high-frequency stimulation of Ia afferents. Also, there is evidence that spinal cord interneurons exhibit plateau potentials. However, to our knowledge, there are no reports about the possible afterdischarge behavior of lumbar spinal interneurons activated by Ia afferents. Given that there are spinal interneurons receiving monosynaptic inputs from Ia afferents, these cells could then be activated in parallel to motoneurons after repetitive muscle stretch. We explored this possibility in cats with a precollicular-postmammillary decerebration. We found that a brief high-frequency stimulation of Ia afferents produces afterdischarges that are highly correlated to a DC slow potential recorded at the cord dorsum. We conclude that in the cat spinal cord, not only the motoneurons but also the interneurons from the superficial and deep dorsal horn produce sustained afterdischarges, thus highlighting the importance of interneurons in the spinal neuronal circuitry. The significance of our finding is that it opens the possibility that the spinal cord interneurons activated by Ia afferents could also exhibit bistability, a relevant phenomenon well-characterized in the motoneurons.
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spelling pubmed-69926512020-02-07 Afterdischarges of Spinal Interneurons Following a Brief High-Frequency Stimulation of Ia Afferents in the Cat Méndez-Fernández, Abraham Moreno-Castillo, Mayra Huidobro, Nayeli Flores, Amira Manjarrez, Elias Front Integr Neurosci Neuroscience Spinal motoneurons exhibit sustained afterdischarges and plateau potentials following a brief high-frequency stimulation of Ia afferents. Also, there is evidence that spinal cord interneurons exhibit plateau potentials. However, to our knowledge, there are no reports about the possible afterdischarge behavior of lumbar spinal interneurons activated by Ia afferents. Given that there are spinal interneurons receiving monosynaptic inputs from Ia afferents, these cells could then be activated in parallel to motoneurons after repetitive muscle stretch. We explored this possibility in cats with a precollicular-postmammillary decerebration. We found that a brief high-frequency stimulation of Ia afferents produces afterdischarges that are highly correlated to a DC slow potential recorded at the cord dorsum. We conclude that in the cat spinal cord, not only the motoneurons but also the interneurons from the superficial and deep dorsal horn produce sustained afterdischarges, thus highlighting the importance of interneurons in the spinal neuronal circuitry. The significance of our finding is that it opens the possibility that the spinal cord interneurons activated by Ia afferents could also exhibit bistability, a relevant phenomenon well-characterized in the motoneurons. Frontiers Media S.A. 2020-01-24 /pmc/articles/PMC6992651/ /pubmed/32038185 http://dx.doi.org/10.3389/fnint.2019.00075 Text en Copyright © 2020 Méndez-Fernández, Moreno-Castillo, Huidobro, Flores and Manjarrez. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Méndez-Fernández, Abraham
Moreno-Castillo, Mayra
Huidobro, Nayeli
Flores, Amira
Manjarrez, Elias
Afterdischarges of Spinal Interneurons Following a Brief High-Frequency Stimulation of Ia Afferents in the Cat
title Afterdischarges of Spinal Interneurons Following a Brief High-Frequency Stimulation of Ia Afferents in the Cat
title_full Afterdischarges of Spinal Interneurons Following a Brief High-Frequency Stimulation of Ia Afferents in the Cat
title_fullStr Afterdischarges of Spinal Interneurons Following a Brief High-Frequency Stimulation of Ia Afferents in the Cat
title_full_unstemmed Afterdischarges of Spinal Interneurons Following a Brief High-Frequency Stimulation of Ia Afferents in the Cat
title_short Afterdischarges of Spinal Interneurons Following a Brief High-Frequency Stimulation of Ia Afferents in the Cat
title_sort afterdischarges of spinal interneurons following a brief high-frequency stimulation of ia afferents in the cat
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992651/
https://www.ncbi.nlm.nih.gov/pubmed/32038185
http://dx.doi.org/10.3389/fnint.2019.00075
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