Brain Activations to Dyspnea in Patients With COPD

We compared the perception and neural processing of respiratory sensations between 20 COPD patients and 20 healthy controls by means of respiratory-related evoked potentials (RREP) in the electroencephalogram (EEG). RREPs were induced by short inspiratory occlusions while 129-channel EEG was measure...

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Autores principales: Reijnders, Thomas, Troosters, Thierry, Janssens, Wim, Gosselink, Rik, Langer, Daniel, Davenport, Paul W., von Leupoldt, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992658/
https://www.ncbi.nlm.nih.gov/pubmed/32038311
http://dx.doi.org/10.3389/fphys.2020.00007
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author Reijnders, Thomas
Troosters, Thierry
Janssens, Wim
Gosselink, Rik
Langer, Daniel
Davenport, Paul W.
von Leupoldt, Andreas
author_facet Reijnders, Thomas
Troosters, Thierry
Janssens, Wim
Gosselink, Rik
Langer, Daniel
Davenport, Paul W.
von Leupoldt, Andreas
author_sort Reijnders, Thomas
collection PubMed
description We compared the perception and neural processing of respiratory sensations between 20 COPD patients and 20 healthy controls by means of respiratory-related evoked potentials (RREP) in the electroencephalogram (EEG). RREPs were induced by short inspiratory occlusions while 129-channel EEG was measured. COPD patients rated the occlusions as more intense and unpleasant (p’s < 0.001) and showed higher mean amplitudes for the RREP components P1 (p = 0.0004), N1 (p = 0.024), P2 (p = 0.019), and P3 (p = 0.018). Our results indicate that COPD patients demonstrate greater perception and neural processing of respiratory sensations, which presumably reflects the highly aversive and attention-demanding character of these sensations for COPD patients.
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spelling pubmed-69926582020-02-07 Brain Activations to Dyspnea in Patients With COPD Reijnders, Thomas Troosters, Thierry Janssens, Wim Gosselink, Rik Langer, Daniel Davenport, Paul W. von Leupoldt, Andreas Front Physiol Physiology We compared the perception and neural processing of respiratory sensations between 20 COPD patients and 20 healthy controls by means of respiratory-related evoked potentials (RREP) in the electroencephalogram (EEG). RREPs were induced by short inspiratory occlusions while 129-channel EEG was measured. COPD patients rated the occlusions as more intense and unpleasant (p’s < 0.001) and showed higher mean amplitudes for the RREP components P1 (p = 0.0004), N1 (p = 0.024), P2 (p = 0.019), and P3 (p = 0.018). Our results indicate that COPD patients demonstrate greater perception and neural processing of respiratory sensations, which presumably reflects the highly aversive and attention-demanding character of these sensations for COPD patients. Frontiers Media S.A. 2020-01-24 /pmc/articles/PMC6992658/ /pubmed/32038311 http://dx.doi.org/10.3389/fphys.2020.00007 Text en Copyright © 2020 Reijnders, Troosters, Janssens, Gosselink, Langer, Davenport and von Leupoldt. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Reijnders, Thomas
Troosters, Thierry
Janssens, Wim
Gosselink, Rik
Langer, Daniel
Davenport, Paul W.
von Leupoldt, Andreas
Brain Activations to Dyspnea in Patients With COPD
title Brain Activations to Dyspnea in Patients With COPD
title_full Brain Activations to Dyspnea in Patients With COPD
title_fullStr Brain Activations to Dyspnea in Patients With COPD
title_full_unstemmed Brain Activations to Dyspnea in Patients With COPD
title_short Brain Activations to Dyspnea in Patients With COPD
title_sort brain activations to dyspnea in patients with copd
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992658/
https://www.ncbi.nlm.nih.gov/pubmed/32038311
http://dx.doi.org/10.3389/fphys.2020.00007
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