Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy

Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus and newborn. Monoclonal IgG anti-Ds (mAb-Ds) would enable unlimited supplies but have differed in efficacy in FcγRIIIa-mediated ADCC assays and clinical trials. Structural variations of the oligosaccharide chains...

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Detalles Bibliográficos
Autores principales: Kumpel, Belinda M., Saldova, Radka, Koeleman, Carolien A. M., Abrahams, Jodie L., Ederveen, Agnes Hipgrave, Armour, Kathryn L., Olovnikova, Natalia I., Vidarsson, Gestur, Kapur, Rick, Rudd, Pauline M., Wuhrer, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992666/
https://www.ncbi.nlm.nih.gov/pubmed/32001734
http://dx.doi.org/10.1038/s41598-019-57393-9

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